{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Rong HM"],"pubmed_abstract":["<h4>Background</h4><i>Pneumocystis</i> pneumonia (PCP) is a common medical issue in immunosuppressive patients. Increasing evidence supports that B cells may play an essential role in PCP individuals. The present study aims to integrate lncRNA and mRNA expression profiles and further investigate the molecular function of mature B cells in PCP.<h4>Methods</h4>The lung tissue of wild-type (WT) mice and B-cell-activating factor receptor-deficient (mature B-cell deficiency, BAFF-R<sup>-/-</sup>) mice were harvested at 3 weeks after being infected with pneumocystis. After total RNAs were extracted, transcriptome profiling was performed following the Illumina HiSeq 3000 protocol. lncRNA-targeted miRNA pairs were predicted using the online databases. The Kyoto Encyclopedia of Genes and Genomes (K"],"journal":["Frontiers in immunology"],"pagination":["898660"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9238325"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of lncRNA and mRNA Repertoires in Lung From BAFF-R-Deficient <i>Pneumocystis</i>-Infected Mice."],"pmcid":["PMC9238325"],"pubmed_authors":["Rong GS","Qian XJ","Li T","Wang D","Tong ZH","Rong HM","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of lncRNA and mRNA Repertoires in Lung From BAFF-R-Deficient <i>Pneumocystis</i>-Infected Mice.","description":"<h4>Background</h4><i>Pneumocystis</i> pneumonia (PCP) is a common medical issue in immunosuppressive patients. Increasing evidence supports that B cells may play an essential role in PCP individuals. The present study aims to integrate lncRNA and mRNA expression profiles and further investigate the molecular function of mature B cells in PCP.<h4>Methods</h4>The lung tissue of wild-type (WT) mice and B-cell-activating factor receptor-deficient (mature B-cell deficiency, BAFF-R<sup>-/-</sup>) mice were harvested at 3 weeks after being infected with pneumocystis. After total RNAs were extracted, transcriptome profiling was performed following the Illumina HiSeq 3000 protocol. lncRNA-targeted miRNA pairs were predicted using the online databases. The Kyoto Encyclopedia of Genes and Genomes (K","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T14:24:39.501Z","creation":"2022-07-10T07:55:51.121Z"},"accession":"S-EPMC9238325","cross_references":{"pubmed":["35774783"],"doi":["10.3389/fimmu.2022.898660"]}}