biostudies-literatureUnknown13Rong HM<h4>Background</h4><i>Pneumocystis</i> pneumonia (PCP) is a common medical issue in immunosuppressive patients. Increasing evidence supports that B cells may play an essential role in PCP individuals. The present study aims to integrate lncRNA and mRNA expression profiles and further investigate the molecular function of mature B cells in PCP.<h4>Methods</h4>The lung tissue of wild-type (WT) mice and B-cell-activating factor receptor-deficient (mature B-cell deficiency, BAFF-R^-/-) mice were harvested at 3 weeks after being infected with pneumocystis. After total RNAs were extracted, transcriptome profiling was performed following the Illumina HiSeq 3000 protocol. lncRNA-targeted miRNA pairs were predicted using the online databases. The Kyoto Encyclopedia of Genes and Genomes (KFrontiers in immunology898660https://www.ebi.ac.uk/biostudies/studies/S-EPMC9238325biostudies-literatureAnalysis of lncRNA and mRNA Repertoires in Lung From BAFF-R-Deficient <i>Pneumocystis</i>-Infected Mice.PMC9238325Rong GSQian XJLi TWang DTong ZHRong HMZhang CfalseAnalysis of lncRNA and mRNA Repertoires in Lung From BAFF-R-Deficient <i>Pneumocystis</i>-Infected Mice.<h4>Background</h4><i>Pneumocystis</i> pneumonia (PCP) is a common medical issue in immunosuppressive patients. Increasing evidence supports that B cells may play an essential role in PCP individuals. The present study aims to integrate lncRNA and mRNA expression profiles and further investigate the molecular function of mature B cells in PCP.<h4>Methods</h4>The lung tissue of wild-type (WT) mice and B-cell-activating factor receptor-deficient (mature B-cell deficiency, BAFF-R^-/-) mice were harvested at 3 weeks after being infected with pneumocystis. After total RNAs were extracted, transcriptome profiling was performed following the Illumina HiSeq 3000 protocol. lncRNA-targeted miRNA pairs were predicted using the online databases. The Kyoto Encyclopedia of Genes and Genomes (K2022-01-01T00:00:00Z20222025-04-05T14:24:39.501Z2022-07-10T07:55:51.121ZS-EPMC92383253577478310.3389/fimmu.2022.898660