biostudies-literatureWells AINIAID NIH HHSHHS | NIH | National Institute of Allergy and Infectious Diseasese0044322https://www.ebi.ac.uk/biostudies/studies/S-EPMC9239134biostudies-literatureUnknown13(3)Enteroviruses are among the most common viral infectious agents of humans and cause a broad spectrum of mild-to-severe illness. Enteroviruses are transmitted primarily by the fecal-oral route, but the events associated with their intestinal replication <i>in vivo</i> are poorly defined. Here, we developed a neonatal mouse model of enterovirus infection by the enteral route using echovirus 5 and used this model to define the differential roles of type I and III interferons (IFNs) in enterovirus replication in the intestinal epithelium and subsequent dissemination to secondary tissues. We show that human neonatal Fc receptor (FcRn), the primary receptor for echoviruses, is essential for intestinal infection by the enteral route and that type I IFNs control dissemination to secondary sites, imBioEnterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract.PMC9239134F31 AI149866R01 AI150151AI149866T32 AI060525AI150151AI060525Coyne CBGrimes KAWells AIfalseEnterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract.Enteroviruses are among the most common viral infectious agents of humans and cause a broad spectrum of mild-to-severe illness. Enteroviruses are transmitted primarily by the fecal-oral route, but the events associated with their intestinal replication <i>in vivo</i> are poorly defined. Here, we developed a neonatal mouse model of enterovirus infection by the enteral route using echovirus 5 and used this model to define the differential roles of type I and III interferons (IFNs) in enterovirus replication in the intestinal epithelium and subsequent dissemination to secondary tissues. We show that human neonatal Fc receptor (FcRn), the primary receptor for echoviruses, is essential for intestinal infection by the enteral route and that type I IFNs control dissemination to secondary sites, i2022-01-01T00:00:00Z2022 Jun2026-06-10T06:19:35.327Z2022-07-08T07:13:04.623ZS-EPMC92391343560412210.1128/mbio.00443-22