{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Howard TR"],"funding":["Edward Mallinckrodt, Jr. Foundation","HHS | NIH | National Institute of General Medical Sciences","Princeton Catalysis Initiative","NIGMS NIH HHS","National Science Foundation"],"pagination":["e0019822"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9239196"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(3)"],"pubmed_abstract":["Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors. The interferon-inducible protein 16 (IFI16) is a nuclear DNA sensor that recognizes double-stranded DNA from a number of viral sources, including genomes of nuclear-replicating viruses. Among these is the prevalent human pathogen herpes simplex virus 1 (HSV-1). Upon binding to the HSV-1 DNA genome, IFI16 both induces antiviral cytokine expression and suppresses virus gene expression. Here, we used a multiomics approach of DNA sequencing techniques paired with targeted mass spectrometry to obtain an extensive view of the interaction between IFI16 and the HSV-1 genome and how this binding affects the viral DNA structure and protein expre"],"journal":["mSystems"],"pubmed_title":["The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection."],"pmcid":["PMC9239196"],"funding_grant_id":["T32 GM007388","GM114141","DGE-1656466","R01 GM114141","T32-GM007388"],"pubmed_authors":["Kennedy MA","Cristea IM","Howard TR","Lum KK"],"additional_accession":[]},"is_claimable":false,"name":"The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection.","description":"Human cells identify invading pathogens and activate immune signaling pathways through a wide array of pattern recognition receptors, including DNA sensors. The interferon-inducible protein 16 (IFI16) is a nuclear DNA sensor that recognizes double-stranded DNA from a number of viral sources, including genomes of nuclear-replicating viruses. Among these is the prevalent human pathogen herpes simplex virus 1 (HSV-1). Upon binding to the HSV-1 DNA genome, IFI16 both induces antiviral cytokine expression and suppresses virus gene expression. Here, we used a multiomics approach of DNA sequencing techniques paired with targeted mass spectrometry to obtain an extensive view of the interaction between IFI16 and the HSV-1 genome and how this binding affects the viral DNA structure and protein expre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-22T03:15:42.666Z","creation":"2024-12-04T07:52:03.905Z"},"accession":"S-EPMC9239196","cross_references":{"pubmed":["35575489"],"doi":["10.1128/msystems.00198-22"]}}