{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou J"],"funding":["Natural Science Foundation of Tianjin City","National Natural Science Foundation of China","Science &amp; Technology Development Fund of Tianjin Education Commission for Higher Education"],"pagination":["278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9241272"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["<h4>Background</h4>Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption. However, it remains to be clarified whether and how OSMR affects the differentiation of osteoblasts.<h4>Methods</h4>The expression level of OSMR during osteoblast and adipocyte differentiation was examined. The role of OSMR in the differentiation was investigated using in vitro gain-of-function and loss-of-function experiments. The mechanisms by which OSMR regulates bone cell differentiation were explored. Finally, in vivo function of OSMR in cell fate determination and bone homeostasis was studied after transplantation of OSMR-silenced bone marrow stromal cells (BMSCs) to the marrow of o"],"journal":["Stem cell research & therapy"],"pubmed_title":["Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling."],"pmcid":["PMC9241272"],"funding_grant_id":["18JCQNJC12900","82072389","2017KJ213","19JCYBJC25400","82002263"],"pubmed_authors":["Li X","Yang J","Dong Y","Wang B","Zhu E","Yuan H","Zhou J","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.","description":"<h4>Background</h4>Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption. However, it remains to be clarified whether and how OSMR affects the differentiation of osteoblasts.<h4>Methods</h4>The expression level of OSMR during osteoblast and adipocyte differentiation was examined. The role of OSMR in the differentiation was investigated using in vitro gain-of-function and loss-of-function experiments. The mechanisms by which OSMR regulates bone cell differentiation were explored. Finally, in vivo function of OSMR in cell fate determination and bone homeostasis was studied after transplantation of OSMR-silenced bone marrow stromal cells (BMSCs) to the marrow of o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-05T12:39:17.601Z","creation":"2022-07-08T16:04:22.7Z"},"accession":"S-EPMC9241272","cross_references":{"pubmed":["35765036"],"doi":["10.1186/s13287-022-02958-1"]}}