biostudies-literaturePierre-Louis ENIAID NIH HHSHHS | NIH | National Institute of Allergy and Infectious Diseasese0016022https://www.ebi.ac.uk/biostudies/studies/S-EPMC9241542biostudies-literatureUnknown7(3)The protozoan Toxoplasma gondii is a highly successful obligate intracellular parasite that, upon invasion of its host cell, releases an array of host-modulating protein effectors to counter host defenses and further its own replication and dissemination. Early studies investigating the impact of T. gondii infection on host cell function revealed that this parasite can force normally quiescent cells to activate their cell cycle program. Prior reports by two independent groups identified the dense granule protein effector HCE1/TEEGR as being solely responsible for driving host cell transcriptional changes through its direct interaction with the cyclin E regulatory complex DP1 and associated transcription factors. Our group independently identified HCE1/TEEGR through the presence of distinctmSphereDisruption of Toxoplasma gondii-Induced Host Cell DNA Replication Is Dependent on Contact Inhibition and Host Cell Type.PMC9241542R21 AI142431T32 AI060546R21AI142431T32AI060546Etheridge MGChasen NMPierre-Louis Ede Paula Baptista REtheridge RDKhan AfalseDisruption of Toxoplasma gondii-Induced Host Cell DNA Replication Is Dependent on Contact Inhibition and Host Cell Type.The protozoan Toxoplasma gondii is a highly successful obligate intracellular parasite that, upon invasion of its host cell, releases an array of host-modulating protein effectors to counter host defenses and further its own replication and dissemination. Early studies investigating the impact of T. gondii infection on host cell function revealed that this parasite can force normally quiescent cells to activate their cell cycle program. Prior reports by two independent groups identified the dense granule protein effector HCE1/TEEGR as being solely responsible for driving host cell transcriptional changes through its direct interaction with the cyclin E regulatory complex DP1 and associated transcription factors. Our group independently identified HCE1/TEEGR through the presence of distinct2022-01-01T00:00:00Z2022 Jun2026-06-15T05:57:00.058Z2024-11-13T21:48:10.816ZS-EPMC92415423558765810.1128/msphere.00160-22