{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao J"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["7536-7540"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9242012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(25)"],"pubmed_abstract":["Pyrrolidine, an important feedstock in the chemical industry, is commonly produced <i>via</i> vapor-phase catalytic ammoniation of tetrahydrofuran (THF). Obtaining pyrrolidine with high purity and low energy cost has extremely high economic and environmental values. Here we offer a rapid and energy-saving method for adsorptive separation of pyrrolidine and THF by using nonporous adaptive crystals of per-ethyl pillar[6]arene (EtP6). EtP6 crystals show a superior preference towards pyrrolidine in 50 : 50 (v/v) pyrrolidine/THF mixture vapor, resulting in rapid separation. The purity of pyrrolidine reaches 95% in 15 min of separation, and after 2 h, the purity is found to be 99.9%. Single-crystal structures demonstrate that the selectivity is based on the stability difference of host-guest structures after uptake of THF or pyrrolidine and non-covalent interactions in the crystals. Besides, EtP6 crystals can be recycled efficiently after the separation process owing to reversible transformations between the guest-free and guest-loaded EtP6."],"journal":["Chemical science"],"pubmed_title":["Separation of pyrrolidine from tetrahydrofuran by using pillar[6]arene-based nonporous adaptive crystals."],"pmcid":["PMC9242012"],"funding_grant_id":["22035006","LD21B020001","2021YFA0910100"],"pubmed_authors":["Liu Y","Huang F","Jie K","Cao J","Li Q","Zhu H","Zhu W","Wang Z","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Separation of pyrrolidine from tetrahydrofuran by using pillar[6]arene-based nonporous adaptive crystals.","description":"Pyrrolidine, an important feedstock in the chemical industry, is commonly produced <i>via</i> vapor-phase catalytic ammoniation of tetrahydrofuran (THF). Obtaining pyrrolidine with high purity and low energy cost has extremely high economic and environmental values. Here we offer a rapid and energy-saving method for adsorptive separation of pyrrolidine and THF by using nonporous adaptive crystals of per-ethyl pillar[6]arene (EtP6). EtP6 crystals show a superior preference towards pyrrolidine in 50 : 50 (v/v) pyrrolidine/THF mixture vapor, resulting in rapid separation. The purity of pyrrolidine reaches 95% in 15 min of separation, and after 2 h, the purity is found to be 99.9%. Single-crystal structures demonstrate that the selectivity is based on the stability difference of host-guest structures after uptake of THF or pyrrolidine and non-covalent interactions in the crystals. Besides, EtP6 crystals can be recycled efficiently after the separation process owing to reversible transformations between the guest-free and guest-loaded EtP6.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-09T23:42:21.331Z","creation":"2025-04-04T22:12:17.747Z"},"accession":"S-EPMC9242012","cross_references":{"pubmed":["35872814"],"doi":["10.1039/d2sc02494b"]}}