{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Adua E"],"funding":["School of Science, Edith Cowan University"],"pubmed_abstract":["Plasma N-glycan profiles have been shown to be defective in type II diabetes Mellitus (T2DM) and holds a promise to discovering biomarkers. The study comprised 232 T2DM patients and 219 healthy individuals. N-glycans were analysed by high-performance liquid chromatography. The multivariate integrative framework, DIABLO was employed for the statistical analysis. N-glycan groups (GPs 34, 32, 26, 31, 36 and 30) were significantly expressed in T2DM in component 1 and GPs 38 and 20 were related to T2DM in component 2. Four clusters were observed based on the correlation of the expressive signatures of the 39 N-glycans across T2DM and controls. Cluster A, B, C and D had 16, 16, 4 and 3 N-glycans respectively, of which 11, 8, 1 and 1 were found to express differently between controls and T2DM in "],"journal":["Scientific reports"],"pagination":["10974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9243128"],"repository":["biostudies-literature"],"pubmed_title":["Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus."],"pmcid":["PMC9243128"],"pubmed_authors":["Peprah-Yamoah E","Acheampong E","Awuah-Mensah KA","Adua E","Wang W","Anto EO","Afrifa-Yamoah E"],"additional_accession":[]},"is_claimable":false,"name":"Multi-block data integration analysis for identifying and validating targeted N-glycans as biomarkers for type II diabetes mellitus.","description":"Plasma N-glycan profiles have been shown to be defective in type II diabetes Mellitus (T2DM) and holds a promise to discovering biomarkers. The study comprised 232 T2DM patients and 219 healthy individuals. N-glycans were analysed by high-performance liquid chromatography. The multivariate integrative framework, DIABLO was employed for the statistical analysis. N-glycan groups (GPs 34, 32, 26, 31, 36 and 30) were significantly expressed in T2DM in component 1 and GPs 38 and 20 were related to T2DM in component 2. Four clusters were observed based on the correlation of the expressive signatures of the 39 N-glycans across T2DM and controls. Cluster A, B, C and D had 16, 16, 4 and 3 N-glycans respectively, of which 11, 8, 1 and 1 were found to express differently between controls and T2DM in ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-03T08:21:19.326Z","creation":"2022-07-08T09:05:55.875Z"},"accession":"S-EPMC9243128","cross_references":{"pubmed":["35768493"],"doi":["10.1038/s41598-022-15172-z"]}}