{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coverdale JPC"],"funding":["Leverhulme Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["7384-7387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9244874"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(53)"],"pubmed_abstract":["The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["Albumin-mediated extracellular zinc speciation drives cellular zinc uptake."],"pmcid":["PMC9244874"],"funding_grant_id":["RPG-2017-214","BB/J006467/1","BB/V014684/1"],"pubmed_authors":["Coverdale JPC","Khazaipoul S","Blindauer CA","van den Berg HA","Stewart AJ","Bridgewater HE"],"additional_accession":[]},"is_claimable":false,"name":"Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.","description":"The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-27T20:27:53.182Z","creation":"2025-02-19T02:43:12.835Z"},"accession":"S-EPMC9244874","cross_references":{"pubmed":["35695483"],"doi":["10.1039/d2cc02278h"]}}