biostudies-literatureCoverdale JPCLeverhulme TrustBiotechnology and Biological Sciences Research Council7384-7387https://www.ebi.ac.uk/biostudies/studies/S-EPMC9244874biostudies-literatureUnknown58(53)The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.Chemical communications (Cambridge, England)Albumin-mediated extracellular zinc speciation drives cellular zinc uptake.PMC9244874RPG-2017-214BB/J006467/1BB/V014684/1Coverdale JPCKhazaipoul SBlindauer CAvan den Berg HAStewart AJBridgewater HEfalseAlbumin-mediated extracellular zinc speciation drives cellular zinc uptake.The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.2022-01-01T00:00:00Z2022 Jun2026-05-27T20:27:53.182Z2025-02-19T02:43:12.835ZS-EPMC92448743569548310.1039/d2cc02278h