biostudies-literatureUnknown13Cherubini V<h4>Aim/hypothesis</h4>To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in Italy during the COVID-19 pandemic in 2020 with the frequency of DKA during 2017-2019.<h4>Methods</h4>Forty-seven pediatric diabetes centers caring for >90% of young people with diabetes in Italy recruited 4,237 newly diagnosed children with type 1 diabetes between 2017 and 2020 in a longitudinal study. Four subperiods in 2020 were defined based on government-imposed containment measures for COVID-19, and the frequencies of DKA and severe DKA compared with the same periods in 2017-2019.<h4>Results</h4>Overall, the frequency of DKA increased from 35.7% (95%CI, 33.5-36.9) in 2017-2019 to 39.6% (95%CI, 36.7-42.4) in 2020 (p=0.008), while the frequency of severe DKA increased from Frontiers in endocrinology878634https://www.ebi.ac.uk/biostudies/studies/S-EPMC9247264biostudies-literatureThe Silent Epidemic of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents in Italy During the COVID-19 Pandemic in 2020.PMC9247264Ortolani FPozzi EBobbio ARipoli CGesuita RMozzillo EPredieri BTiberi VMameli CGiannini CZampolli MMarigliano MBassi MCherubini VGallo FRicciardi MRBruzzi PMaltoni GDe Donno VRigamonti AFrontino GFelappi BIannilli ACalcaterra VArnaldi CMacedoni MPiscopo ATinti DScaramuzza AETornese GZanfardino ALasagni AFranzese ACauvin VMonti SD'Annunzio GDe Marco RGrosso CZucchini SDe Sanctis LCardinale GPampanini VBerioli MGMoretti CRutigliano IRabbone IMaffeis CSchiaffini RFranceschi RPiccinno EInnaurato SGraziani VBracciolini GPGuerraggio LPMusolino GCitriniti FTalarico VBonfanti RPiccini BPatera PIPascarella FLombardo FMarino MIovane BChiarelli FIafusco DMinuto NBombaci BDelvecchio MLenzi LCurto SSordelli SCardella FDe Berardinis FToni SRosanio FFranco FPiredda GMatteoli MCTrada MStamati FAMeloni GRollato ASCoccioli SfalseThe Silent Epidemic of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Children and Adolescents in Italy During the COVID-19 Pandemic in 2020.<h4>Aim/hypothesis</h4>To compare the frequency of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes in Italy during the COVID-19 pandemic in 2020 with the frequency of DKA during 2017-2019.<h4>Methods</h4>Forty-seven pediatric diabetes centers caring for >90% of young people with diabetes in Italy recruited 4,237 newly diagnosed children with type 1 diabetes between 2017 and 2020 in a longitudinal study. Four subperiods in 2020 were defined based on government-imposed containment measures for COVID-19, and the frequencies of DKA and severe DKA compared with the same periods in 2017-2019.<h4>Results</h4>Overall, the frequency of DKA increased from 35.7% (95%CI, 33.5-36.9) in 2017-2019 to 39.6% (95%CI, 36.7-42.4) in 2020 (p=0.008), while the frequency of severe DKA increased from 2022-01-01T00:00:00Z20222025-04-04T21:41:11.618Z2022-07-08T07:55:50.551ZS-EPMC92472643578455010.3389/fendo.2022.878634