{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Tassinari CJ"],"pubmed_abstract":["<h4>Introduction</h4>Knee replacement (KR) is a clinically proven procedure typically offered to patients with severe knee osteoarthritis (OA) to relieve pain and improve quality of life. However, artificial joints fail over time, requiring revision associated with higher mortality and inferior outcomes. With more young people presenting with knee OA and increasing life expectancy, there is an unmet need to postpone time to first KR. Knee joint distraction (KJD), the practice of using external fixators to open up knee joint space, is proposed as potentially effective to preserve the joint following initial studies in the Netherlands, however, has not been researched within an NHS setting. The KARDS trial will investigate whether KJD is non-inferior to KR in terms of patient-reported postop"],"journal":["BMJ open"],"pagination":["e062721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9247693"],"repository":["biostudies-literature"],"pubmed_title":["Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial."],"pmcid":["PMC9247693"],"pubmed_authors":["Hamilton TW","Smith IL","Mujica-Mota R","Arnold S","Sharma H","Fernandez C","Ellard DR","Higham R","Harwood P","Croft J","Tassinari CJ","Murray D","Stocken DD","Pandit H","Simpson H","Reynolds C","Metcalfe A","McGonagle DG"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial.","description":"<h4>Introduction</h4>Knee replacement (KR) is a clinically proven procedure typically offered to patients with severe knee osteoarthritis (OA) to relieve pain and improve quality of life. However, artificial joints fail over time, requiring revision associated with higher mortality and inferior outcomes. With more young people presenting with knee OA and increasing life expectancy, there is an unmet need to postpone time to first KR. Knee joint distraction (KJD), the practice of using external fixators to open up knee joint space, is proposed as potentially effective to preserve the joint following initial studies in the Netherlands, however, has not been researched within an NHS setting. The KARDS trial will investigate whether KJD is non-inferior to KR in terms of patient-reported postop","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T20:41:26.504Z","creation":"2025-04-04T20:41:26.504Z"},"accession":"S-EPMC9247693","cross_references":{"pubmed":["35772819"],"doi":["10.1136/bmjopen-2022-062721"]}}