{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(5)"],"submitter":["Azhar S"],"pubmed_abstract":["Background & objective
This study aimed to assess the clinical effectiveness of Hydroxychloroquine Sulfate (200 mg orally 8 hourlies thrice a day for 5 days), oseltamivir (75 mg orally twice a day for 5 days), and Azithromycin (500 mg orally daily on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in seven groups).Methods & analysis
An adaptive design is deployed, set within a comprehensive cohort study, to permit flexibility in fast-changing clinical and public health scenario. Primary outcomes include turning the test negative for coronavirus nucliec acid and in bringing about clinical improvement on day 7 of follow-up on a seven-point ordinal scale. The randomized study will recruit participants of either gender above 18 years of age w"],"journal":["Pakistan journal of medical sciences"],"pagination":["1401-1408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9247782"],"repository":["biostudies-literature"],"pubmed_title":["Protocol of Pakistan randomized and observational trial to evaluate coronavirus treatment among newly diagnosed patients with COVID-19: Azithromycin, Oseltamivir, and Hydroxychloquine."],"pmcid":["PMC9247782"],"pubmed_authors":["Latif W","Akram J","Azhar S","Khan KS","Shahzad M"],"additional_accession":[]},"is_claimable":false,"name":"Protocol of Pakistan randomized and observational trial to evaluate coronavirus treatment among newly diagnosed patients with COVID-19: Azithromycin, Oseltamivir, and Hydroxychloquine.","description":"Background & objective
This study aimed to assess the clinical effectiveness of Hydroxychloroquine Sulfate (200 mg orally 8 hourlies thrice a day for 5 days), oseltamivir (75 mg orally twice a day for 5 days), and Azithromycin (500 mg orally daily on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in seven groups).Methods & analysis
An adaptive design is deployed, set within a comprehensive cohort study, to permit flexibility in fast-changing clinical and public health scenario. Primary outcomes include turning the test negative for coronavirus nucliec acid and in bringing about clinical improvement on day 7 of follow-up on a seven-point ordinal scale. The randomized study will recruit participants of either gender above 18 years of age w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May-Jun","modification":"2025-04-04T13:27:34.498Z","creation":"2025-04-04T13:27:34.498Z"},"accession":"S-EPMC9247782","cross_references":{"pubmed":["35799756"],"doi":["10.12669/pjms.38.5.5512"]}}