{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zarrella TM"],"funding":["Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e3001679"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9249247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(6)"],"pubmed_abstract":["Bacteria typically exist in dynamic, multispecies communities where polymicrobial interactions influence fitness. Elucidating the molecular mechanisms underlying these interactions is critical for understanding and modulating bacterial behavior in natural environments. While bacterial responses to foreign species are frequently characterized at the molecular and phenotypic level, the exogenous molecules that elicit these responses are understudied. Here, we outline a systematic strategy based on transcriptomics combined with genetic and biochemical screens of promoter-reporters to identify the molecules from one species that are sensed by another. We utilized this method to study interactions between the pathogens Pseudomonas aeruginosa and Staphylococcus aureus that are frequently found i"],"journal":["PLoS biology"],"pubmed_title":["Systematic identification of molecular mediators of interspecies sensing in a community of two frequently coinfecting bacterial pathogens."],"pmcid":["PMC9249247"],"funding_grant_id":["FI2 GM137843","1FI2GM137843-01"],"pubmed_authors":["Zarrella TM","Khare A"],"additional_accession":[]},"is_claimable":false,"name":"Systematic identification of molecular mediators of interspecies sensing in a community of two frequently coinfecting bacterial pathogens.","description":"Bacteria typically exist in dynamic, multispecies communities where polymicrobial interactions influence fitness. Elucidating the molecular mechanisms underlying these interactions is critical for understanding and modulating bacterial behavior in natural environments. While bacterial responses to foreign species are frequently characterized at the molecular and phenotypic level, the exogenous molecules that elicit these responses are understudied. Here, we outline a systematic strategy based on transcriptomics combined with genetic and biochemical screens of promoter-reporters to identify the molecules from one species that are sensed by another. We utilized this method to study interactions between the pathogens Pseudomonas aeruginosa and Staphylococcus aureus that are frequently found i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-27T22:45:18.963Z","creation":"2022-07-08T10:55:58.351Z"},"accession":"S-EPMC9249247","cross_references":{"pubmed":["35727825"],"doi":["10.1371/journal.pbio.3001679"]}}