biostudies-literatureCho SNHLBI NIH HHSNational Institutes of HealthNational Heart Lung and Blood Institute102657https://www.ebi.ac.uk/biostudies/studies/S-EPMC9250545biostudies-literatureUnknown59LMNA-related dilated cardiomyopathy (LMNA-DCM) is caused by pathogenic variants in the LMNA gene and is characterized by left ventricular chamber enlargement, reduced systolic function, and arrhythmia. Here, we generated three human induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of three DCM patients carrying the same single heterozygous mutation, c.398 G > A, in LMNA. All lines exhibited normal iPSC morphology, expressed high levels of pluripotency markers, showed normal karyotypes, and could differentiate into the three germ layers. These patient-specific iPSC lines can serve as invaluable tools to model in vitro pathological mechanisms of LMNA-DCM.Stem cell researchHeterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients.PMC9250545P01 HL14108475N92020D00019R01 HL130020F32 HL152483R01 HL150693R01 HL113006Fowler MLee CWu JCHaddad FZhuge YLai CCho SSallam KfalseHeterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients.LMNA-related dilated cardiomyopathy (LMNA-DCM) is caused by pathogenic variants in the LMNA gene and is characterized by left ventricular chamber enlargement, reduced systolic function, and arrhythmia. Here, we generated three human induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of three DCM patients carrying the same single heterozygous mutation, c.398 G > A, in LMNA. All lines exhibited normal iPSC morphology, expressed high levels of pluripotency markers, showed normal karyotypes, and could differentiate into the three germ layers. These patient-specific iPSC lines can serve as invaluable tools to model in vitro pathological mechanisms of LMNA-DCM.2022-01-01T00:00:00Z2022 Mar2024-11-13T10:25:21.416Z2024-11-13T10:25:21.416ZS-EPMC92505453499942310.1016/j.scr.2022.102657