{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(7)"],"submitter":["Li TT"],"pubmed_abstract":["We previously show that L-Cysteine administration significantly suppresses hypoxia-ischemia (HI)-induced neuroinflammation in neonatal mice through releasing H<sub>2</sub>S. In this study we conducted proteomics analysis to explore the potential biomarkers or molecular therapeutic targets associated with anti-inflammatory effect of L-Cysteine in neonatal mice following HI insult. HI brain injury was induced in postnatal day 7 (P7) neonatal mice. The pups were administered L-Cysteine (5 mg/kg) at 24, 48, and 72 h post-HI. By conducting TMT-based proteomics analysis, we confirmed that osteopontin (OPN) was the most upregulated protein in ipsilateral cortex 72 h following HI insult. Moreover, OPN was expressed in CD11b<sup>+</sup>/CD45<sup>low</sup> cells and infiltrating CD11b<sup>+</sup>/CD"],"journal":["Acta pharmacologica Sinica"],"pagination":["1658-1669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9253102"],"repository":["biostudies-literature"],"pubmed_title":["L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3."],"pmcid":["PMC9253102"],"pubmed_authors":["Liu DX","Xin DQ","Yue SW","Chu XL","Zhao YJ","Ke HF","Li TT","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3.","description":"We previously show that L-Cysteine administration significantly suppresses hypoxia-ischemia (HI)-induced neuroinflammation in neonatal mice through releasing H<sub>2</sub>S. In this study we conducted proteomics analysis to explore the potential biomarkers or molecular therapeutic targets associated with anti-inflammatory effect of L-Cysteine in neonatal mice following HI insult. HI brain injury was induced in postnatal day 7 (P7) neonatal mice. The pups were administered L-Cysteine (5 mg/kg) at 24, 48, and 72 h post-HI. By conducting TMT-based proteomics analysis, we confirmed that osteopontin (OPN) was the most upregulated protein in ipsilateral cortex 72 h following HI insult. Moreover, OPN was expressed in CD11b<sup>+</sup>/CD45<sup>low</sup> cells and infiltrating CD11b<sup>+</sup>/CD","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-26T07:41:08.747Z","creation":"2025-04-06T12:22:35.628Z"},"accession":"S-EPMC9253102","cross_references":{"pubmed":["34737419"],"doi":["10.1038/s41401-021-00794-2"]}}