biostudies-literatureUnknown42(5)Wang LPWhite matter injury is a critical pathological characteristic during ischemic stroke. Oligodendrocyte precursor cells participate in white matter repairing and remodeling during ischemic brain injury. Since oligodendrocyte precursor cells could promote Wnt-dependent angiogenesis and migrate along vasculature for the myelination during the development in the central nervous system, we explore whether exogenous oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination after middle cerebral artery occlusion in mice. Here, oligodendrocyte precursor cell transplantation improved motor and cognitive function, and alleviated brain atrophy. Furthermore, oligodendrocyte precursor cell transplantation promoted functional angiogenesis, and increased myelin basic protein eJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism757-770https://www.ebi.ac.uk/biostudies/studies/S-EPMC9254032biostudies-literatureOligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/<b>β</b>-catenin pathway in a mouse model of middle cerebral artery occlusion.PMC9254032Wang LPPan JLi YZhang LYZhou PZhang ZTang YHGeng JLiu CWang YYang GYfalseOligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/<b>β</b>-catenin pathway in a mouse model of middle cerebral artery occlusion.White matter injury is a critical pathological characteristic during ischemic stroke. Oligodendrocyte precursor cells participate in white matter repairing and remodeling during ischemic brain injury. Since oligodendrocyte precursor cells could promote Wnt-dependent angiogenesis and migrate along vasculature for the myelination during the development in the central nervous system, we explore whether exogenous oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination after middle cerebral artery occlusion in mice. Here, oligodendrocyte precursor cell transplantation improved motor and cognitive function, and alleviated brain atrophy. Furthermore, oligodendrocyte precursor cell transplantation promoted functional angiogenesis, and increased myelin basic protein e2022-01-01T00:00:00Z2022 May2025-04-18T20:04:20.124Z2025-04-07T07:50:40.994ZS-EPMC92540323487895810.1177/0271678X21106539110.1177/0271678x211065391