{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye X"],"funding":["Division of Chemistry","National Natural Science Foundation of China","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e202201018"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9254727"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(34)"],"pubmed_abstract":["Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N ligands as the optimal choice, giving alkene aminoarylation with good yields (up to 80 %) and excellent stereoselectivity (up to 99 : 1 er). As the first example of enantioselective gold redox catalysis, this work confirmed the feasibility of applying a chiral ligand at the gold(I) stage, with the stereodetermining step (SDS) at the gold(III) intermediate, thus opening up a new way to conduct gold redox catalysis with stereochemistry control."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Chiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation."],"pmcid":["PMC9254727"],"funding_grant_id":["1R01GM120240-01","CHE-2054180","21629201 and 81874308","R01 GM120240","R01 GM147135"],"pubmed_authors":["Wang C","Tang Q","Zhang S","Wojtas L","Ye X","Li M","Shi X"],"additional_accession":[]},"is_claimable":false,"name":"Chiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation.","description":"Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N ligands as the optimal choice, giving alkene aminoarylation with good yields (up to 80 %) and excellent stereoselectivity (up to 99 : 1 er). As the first example of enantioselective gold redox catalysis, this work confirmed the feasibility of applying a chiral ligand at the gold(I) stage, with the stereodetermining step (SDS) at the gold(III) intermediate, thus opening up a new way to conduct gold redox catalysis with stereochemistry control.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-21T14:20:12.359Z","creation":"2025-04-21T14:20:12.359Z"},"accession":"S-EPMC9254727","cross_references":{"pubmed":["35420241"],"doi":["10.1002/chem.202201018"]}}