biostudies-literatureYe XDivision of ChemistryNational Natural Science Foundation of ChinaNational Institute of General Medical SciencesNIGMS NIH HHSe202201018https://www.ebi.ac.uk/biostudies/studies/S-EPMC9254727biostudies-literatureUnknown28(34)Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N ligands as the optimal choice, giving alkene aminoarylation with good yields (up to 80 %) and excellent stereoselectivity (up to 99 : 1 er). As the first example of enantioselective gold redox catalysis, this work confirmed the feasibility of applying a chiral ligand at the gold(I) stage, with the stereodetermining step (SDS) at the gold(III) intermediate, thus opening up a new way to conduct gold redox catalysis with stereochemistry control.Chemistry (Weinheim an der Bergstrasse, Germany)Chiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation.PMC92547271R01GM120240-01CHE-205418021629201 and 81874308R01 GM120240R01 GM147135Wang CTang QZhang SWojtas LYe XLi MShi XfalseChiral Hemilabile P,N-Ligand-Assisted Gold Redox Catalysis for Enantioselective Alkene Aminoarylation.Enantioselective, intermolecular alkene arylamination was achieved through gold redox catalysis. Screening of ligands revealed chiral P,N ligands as the optimal choice, giving alkene aminoarylation with good yields (up to 80 %) and excellent stereoselectivity (up to 99 : 1 er). As the first example of enantioselective gold redox catalysis, this work confirmed the feasibility of applying a chiral ligand at the gold(I) stage, with the stereodetermining step (SDS) at the gold(III) intermediate, thus opening up a new way to conduct gold redox catalysis with stereochemistry control.2022-01-01T00:00:00Z2022 Jun2025-04-21T14:20:12.359Z2025-04-21T14:20:12.359ZS-EPMC92547273542024110.1002/chem.202201018