{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(2)"],"submitter":["Palassin P"],"pubmed_abstract":["<b>Aim:</b> The transcription factor RIP140 (receptor interacting protein of 140 kDa) is involved in intestinal tumorigenesis. It plays a role in the control of microsatellite instability (MSI), through the regulation of <i>MSH2</i> and <i>MSH6</i> gene expression. The aim of this study was to explore its effect on the expression of <i>POLK</i>, the gene encoding the specialized translesion synthesis (TLS) DNA polymerase κ known to perform accurate DNA synthesis at microsatellites. <b>Methods:</b> Different mouse models and engineered human colorectal cancer (CRC) cell lines were used to analyze by RT-qPCR, while Western blotting and luciferase assays were used to elucidate the role of RIP140 on <i>POLK</i> gene expression. Published DNA microarray datasets were reanalyzed. The <i>in vitro"],"journal":["Cancer drug resistance (Alhambra, Calif.)"],"pagination":["401-414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9255241"],"repository":["biostudies-literature"],"pubmed_title":["RIP140 regulates <i>POLK</i> gene expression and the response to alkylating drugs in colon cancer cells."],"pmcid":["PMC9255241"],"pubmed_authors":["Castet-Nicolas A","Cavailles V","Gyorffy B","Lapierre M","Teyssier C","Pillaire MJ","Hoffmann JS","Palassin P","Bonnet S","Jalaguier S"],"additional_accession":[]},"is_claimable":false,"name":"RIP140 regulates <i>POLK</i> gene expression and the response to alkylating drugs in colon cancer cells.","description":"<b>Aim:</b> The transcription factor RIP140 (receptor interacting protein of 140 kDa) is involved in intestinal tumorigenesis. It plays a role in the control of microsatellite instability (MSI), through the regulation of <i>MSH2</i> and <i>MSH6</i> gene expression. The aim of this study was to explore its effect on the expression of <i>POLK</i>, the gene encoding the specialized translesion synthesis (TLS) DNA polymerase κ known to perform accurate DNA synthesis at microsatellites. <b>Methods:</b> Different mouse models and engineered human colorectal cancer (CRC) cell lines were used to analyze by RT-qPCR, while Western blotting and luciferase assays were used to elucidate the role of RIP140 on <i>POLK</i> gene expression. Published DNA microarray datasets were reanalyzed. The <i>in vitro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T10:43:36.948Z","creation":"2022-07-23T10:14:45.014Z"},"accession":"S-EPMC9255241","cross_references":{"pubmed":["35800380"],"doi":["10.20517/cdr.2021.133"]}}