{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wennerberg E"],"funding":["NCI NIH HHS"],"pagination":["eabe8195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9256502"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(636)"],"pubmed_abstract":["Most patients with non-small cell lung cancer (NSCLC) do not achieve durable clinical responses from immune checkpoint inhibitors, suggesting the existence of additional resistance mechanisms. Nicotinamide adenine dinucleotide (NAD)-induced cell death (NICD) of P2X7 receptor (P2X7R)-expressing T cells regulates immune homeostasis in inflamed tissues. This process is mediated by mono-adenosine 5'-diphosphate (ADP)-ribosyltransferases (ARTs). We found an association between membranous expression of ART1 on tumor cells and reduced CD8 T cell infiltration. Specifically, we observed a reduction in the P2X7R<sup>+</sup> CD8 T cell subset in human lung adenocarcinomas. In vitro, P2X7R<sup>+</sup> CD8 T cells were susceptible to ART1-mediated ADP-ribosylation and NICD, which was exacerbated upon b"],"journal":["Science translational medicine"],"pubmed_title":["Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer."],"pmcid":["PMC9256502"],"funding_grant_id":["R01 CA198533","P30 CA008748"],"pubmed_authors":["Lorenz IC","Adusumilli PS","Hung C","Wennerberg E","Kamel MK","Rudqvist NP","Van Nest SJ","Markowitz GJ","McGraw TE","Demaria S","Valeta-Magara A","White TE","Zhou XK","Khan AG","Balderes PJ","Borczuk AC","Chen C","Altorki N","Stiles BM","Mittal V","Agrusa CJ","Mukherjee S","Narula N","Nasar A","Spada S"],"additional_accession":[]},"is_claimable":false,"name":"Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.","description":"Most patients with non-small cell lung cancer (NSCLC) do not achieve durable clinical responses from immune checkpoint inhibitors, suggesting the existence of additional resistance mechanisms. Nicotinamide adenine dinucleotide (NAD)-induced cell death (NICD) of P2X7 receptor (P2X7R)-expressing T cells regulates immune homeostasis in inflamed tissues. This process is mediated by mono-adenosine 5'-diphosphate (ADP)-ribosyltransferases (ARTs). We found an association between membranous expression of ART1 on tumor cells and reduced CD8 T cell infiltration. Specifically, we observed a reduction in the P2X7R<sup>+</sup> CD8 T cell subset in human lung adenocarcinomas. In vitro, P2X7R<sup>+</sup> CD8 T cells were susceptible to ART1-mediated ADP-ribosylation and NICD, which was exacerbated upon b","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-05-29T19:36:41.589Z","creation":"2024-11-06T07:25:03.791Z"},"accession":"S-EPMC9256502","cross_references":{"pubmed":["35294260"],"doi":["10.1126/scitranslmed.abe8195"]}}