{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Catellani C"],"pubmed_abstract":["<h4>Context</h4>There is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.<h4>Objective</h4>The aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.<h4>Design and methods</h4>The expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t-3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or <-1.5 at t+3 were considered as differentially expressed. <i>In silico</i> analysis of target genes and pathways led to a validati"],"journal":["Frontiers in endocrinology"],"pagination":["896640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9256936"],"repository":["biostudies-literature"],"pubmed_title":["Specific miRNAs Change After 3 Months of GH treatment and Contribute to Explain the Growth Response After 12 Months."],"pmcid":["PMC9256936"],"pubmed_authors":["Cirillo F","Poluzzi S","Street ME","Lazzeroni P","Catellani C","Ravegnini G","Predieri B","Angelini S","Sartori C","Iughetti L","Giorgi Rossi P","Bonvicini L","Righi B"],"additional_accession":[]},"is_claimable":false,"name":"Specific miRNAs Change After 3 Months of GH treatment and Contribute to Explain the Growth Response After 12 Months.","description":"<h4>Context</h4>There is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.<h4>Objective</h4>The aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.<h4>Design and methods</h4>The expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t-3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or <-1.5 at t+3 were considered as differentially expressed. <i>In silico</i> analysis of target genes and pathways led to a validati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T05:23:36.719Z","creation":"2022-07-19T22:39:24.278Z"},"accession":"S-EPMC9256936","cross_references":{"pubmed":["35813630"],"doi":["10.3389/fendo.2022.896640"]}}