biostudies-literatureUnknown13Catellani C<h4>Context</h4>There is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.<h4>Objective</h4>The aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.<h4>Design and methods</h4>The expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t-3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or <-1.5 at t+3 were considered as differentially expressed. <i>In silico</i> analysis of target genes and pathways led to a validatiFrontiers in endocrinology896640https://www.ebi.ac.uk/biostudies/studies/S-EPMC9256936biostudies-literatureSpecific miRNAs Change After 3 Months of GH treatment and Contribute to Explain the Growth Response After 12 Months.PMC9256936Cirillo FPoluzzi SStreet MELazzeroni PCatellani CRavegnini GPredieri BAngelini SSartori CIughetti LGiorgi Rossi PBonvicini LRighi BfalseSpecific miRNAs Change After 3 Months of GH treatment and Contribute to Explain the Growth Response After 12 Months.<h4>Context</h4>There is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.<h4>Objective</h4>The aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.<h4>Design and methods</h4>The expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t-3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or <-1.5 at t+3 were considered as differentially expressed. <i>In silico</i> analysis of target genes and pathways led to a validati2022-01-01T00:00:00Z20222026-05-28T05:23:36.719Z2022-07-19T22:39:24.278ZS-EPMC92569363581363010.3389/fendo.2022.896640