{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hodgson SH"],"funding":["National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["604-610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9257435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["136(7)"],"pubmed_abstract":["<h4>Background</h4>Necrotising otitis externa is a severe ear infection for which there are no established diagnostic or treatment guidelines.<h4>Method</h4>This study described clinical characteristics, management and outcomes for patients managed as necrotising otitis externa cases at a UK tertiary referral centre.<h4>Results</h4>A total of 58 (63 per cent) patients were classified as definite necrotising otitis externa cases, 31 (34 per cent) as probable cases and 3 (3 per cent) as possible cases. Median duration of intravenous and oral antimicrobial therapy was 6.0 weeks (0.49-44.9 weeks). Six per cent of patients relapsed a median of 16.4 weeks (interquartile range, 23-121) after stopping antimicrobials. Twenty-eight per cent of cases had complex disease. These patients were older (<i>p =</i> 0.042), had a longer duration of symptoms prior to imaging (<i>p</i> < 0.0001) and higher C-reactive protein at diagnosis (<i>p =</i> 0.005). Despite longer courses of intravenous antimicrobials (23 <i>vs</i> 14 days<i>; p =</i> 0.032), complex cases were more likely to relapse (<i>p =</i> 0.016).<h4>Conclusion</h4>A standardised case-definition of necrotising otitis externa is needed to optimise diagnosis, management and research."],"journal":["The Journal of laryngology and otology"],"pubmed_title":["Characteristics, management and outcome of a large necrotising otitis externa case series: need for standardised case definition."],"pmcid":["PMC9257435"],"funding_grant_id":["CL-2016-13-008","110110/Z/15/Z"],"pubmed_authors":["Oh K","Ramsden JD","Martinez-Devesa P","Pretorius P","Matthews PC","Sinclair VJ","Sivapathasingam V","Nucken K","Andersson MI","Arwyn-Jones J","Perenyei M","Pendlebury ST","Hodgson SH"],"additional_accession":[]},"is_claimable":false,"name":"Characteristics, management and outcome of a large necrotising otitis externa case series: need for standardised case definition.","description":"<h4>Background</h4>Necrotising otitis externa is a severe ear infection for which there are no established diagnostic or treatment guidelines.<h4>Method</h4>This study described clinical characteristics, management and outcomes for patients managed as necrotising otitis externa cases at a UK tertiary referral centre.<h4>Results</h4>A total of 58 (63 per cent) patients were classified as definite necrotising otitis externa cases, 31 (34 per cent) as probable cases and 3 (3 per cent) as possible cases. Median duration of intravenous and oral antimicrobial therapy was 6.0 weeks (0.49-44.9 weeks). Six per cent of patients relapsed a median of 16.4 weeks (interquartile range, 23-121) after stopping antimicrobials. Twenty-eight per cent of cases had complex disease. These patients were older (<i>p =</i> 0.042), had a longer duration of symptoms prior to imaging (<i>p</i> < 0.0001) and higher C-reactive protein at diagnosis (<i>p =</i> 0.005). Despite longer courses of intravenous antimicrobials (23 <i>vs</i> 14 days<i>; p =</i> 0.032), complex cases were more likely to relapse (<i>p =</i> 0.016).<h4>Conclusion</h4>A standardised case-definition of necrotising otitis externa is needed to optimise diagnosis, management and research.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-18T22:59:35.235Z","creation":"2025-04-07T10:43:33.791Z"},"accession":"S-EPMC9257435","cross_references":{"pubmed":["35042578"],"doi":["10.1017/S002221512100462X"]}}