{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu WL"],"funding":["National Natural Science Foundation of China"],"pagination":["7947-7954"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9258329"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(26)"],"pubmed_abstract":["The transformations that allow the direct removal of hydrogen from their corresponding saturated counterparts by the dehydrogenative strategy are a dream reaction that has remained largely underexplored. In this report, a straightforward and robust cobaloxime-catalyzed photochemical dehydrogenation strategy <i>via</i> intramolecular HAT is described for the first time. The reaction proceeds through an intramolecular radical translocation followed by the cobalt assisted dehydrogenation without needing any other external photosensitizers, noble-metals or oxidants. With this approach, a series of valuable unsaturated compounds such as α,β-unsaturated amides, enamides and allylic and homoallylic sulfonamides were obtained in moderate to excellent yields with good chemo- and regioselectivities, and the synthetic versatility was demonstrated by a range of transformations. And mechanistic studies of the method are discussed."],"journal":["Chemical science"],"pubmed_title":["Cobalt-catalyzed chemoselective dehydrogenation through radical translocation under visible light."],"pmcid":["PMC9258329"],"funding_grant_id":["21632003","21871116","22071085"],"pubmed_authors":["Ma KX","Yang JJ","Yu WL","Zheng H","Xu PF","Yang HQ","Wu W","Ren ZG"],"additional_accession":[]},"is_claimable":false,"name":"Cobalt-catalyzed chemoselective dehydrogenation through radical translocation under visible light.","description":"The transformations that allow the direct removal of hydrogen from their corresponding saturated counterparts by the dehydrogenative strategy are a dream reaction that has remained largely underexplored. In this report, a straightforward and robust cobaloxime-catalyzed photochemical dehydrogenation strategy <i>via</i> intramolecular HAT is described for the first time. The reaction proceeds through an intramolecular radical translocation followed by the cobalt assisted dehydrogenation without needing any other external photosensitizers, noble-metals or oxidants. With this approach, a series of valuable unsaturated compounds such as α,β-unsaturated amides, enamides and allylic and homoallylic sulfonamides were obtained in moderate to excellent yields with good chemo- and regioselectivities, and the synthetic versatility was demonstrated by a range of transformations. And mechanistic studies of the method are discussed.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-05T14:24:48.815Z","creation":"2025-04-05T14:24:48.815Z"},"accession":"S-EPMC9258329","cross_references":{"pubmed":["35865906"],"doi":["10.1039/d2sc02291e"]}}