{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(26)"],"submitter":["You Y"],"pubmed_abstract":["As one of the representative bioorthogonal reactions, the copper-catalyzed click reaction provides a promising approach for <i>in situ</i> prodrug activation in cancer treatment. To solve the issue of inherent toxicity of Cu(i), biocompatible heterogeneous copper nanoparticles (CuNPs) were developed for the Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. However, the unsatisfactory catalytic activity and off-target effect still hindered their application in biological systems. Herein, we constructed a DNAzyme-augmented and targeted bioorthogonal catalyst for synergistic cancer therapy. The system could present specificity to cancer cells and promote the generation of Cu(i) <i>via</i> DNAzyme-induced value state conversion of DNA-templated ultrasmall CuNPs upon exposure to endogen"],"journal":["Chemical science"],"pagination":["7829-7836"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9258401"],"repository":["biostudies-literature"],"pubmed_title":["A DNAzyme-augmented bioorthogonal catalysis system for synergistic cancer therapy."],"pmcid":["PMC9258401"],"pubmed_authors":["Liu H","You Y","Zhu J","Ren J","Qu X","Wang Y","Pu F"],"additional_accession":[]},"is_claimable":false,"name":"A DNAzyme-augmented bioorthogonal catalysis system for synergistic cancer therapy.","description":"As one of the representative bioorthogonal reactions, the copper-catalyzed click reaction provides a promising approach for <i>in situ</i> prodrug activation in cancer treatment. To solve the issue of inherent toxicity of Cu(i), biocompatible heterogeneous copper nanoparticles (CuNPs) were developed for the Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. However, the unsatisfactory catalytic activity and off-target effect still hindered their application in biological systems. Herein, we constructed a DNAzyme-augmented and targeted bioorthogonal catalyst for synergistic cancer therapy. The system could present specificity to cancer cells and promote the generation of Cu(i) <i>via</i> DNAzyme-induced value state conversion of DNA-templated ultrasmall CuNPs upon exposure to endogen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-05T14:24:49.777Z","creation":"2025-04-05T14:24:49.777Z"},"accession":"S-EPMC9258401","cross_references":{"pubmed":["35865897"],"doi":["10.1039/d2sc02050e"]}}