biostudies-literatureJin BWellcome TrustArmy Research LaboratoryNIGMS NIH HHSBiotechnology and Biological Sciences Research Councile202201980https://www.ebi.ac.uk/biostudies/studies/S-EPMC9258440biostudies-literatureUnknown61(14)While bio-inspired synthesis offers great potential for controlling nucleation and growth of inorganic particles, precisely tuning biomolecule-particle interactions is a long-standing challenge. Herein, we used variations in peptoid sequence to manipulate peptoid-Au interactions, leading to the synthesis of concave five-fold twinned, five-pointed Au nanostars via a process of repeated particle attachment and facet stabilization. Ex situ and liquid-phase TEM observations show that a balance between particle attachment biased to occur near the star points, preferential growth along the [100] direction, and stabilization of (111) facets is critical to forming star-shaped particles. Molecular simulations predict that interaction strengths between peptoids and distinct Au facets differ significAngewandte Chemie (International ed. in English)Peptoid-Directed Formation of Five-Fold Twinned Au Nanostars through Particle Attachment and Facet Stabilization.PMC9258440W911NF1920198BB/S003339/1206422/Z/17/ZP50 GM082251R01 GM085043Chen CLTao JFu XNaser NYZhang PCai BDeYoreo JJJin BQi XPfaendtner JZhang XTan SBaneyx FYan FfalsePeptoid-Directed Formation of Five-Fold Twinned Au Nanostars through Particle Attachment and Facet Stabilization.While bio-inspired synthesis offers great potential for controlling nucleation and growth of inorganic particles, precisely tuning biomolecule-particle interactions is a long-standing challenge. Herein, we used variations in peptoid sequence to manipulate peptoid-Au interactions, leading to the synthesis of concave five-fold twinned, five-pointed Au nanostars via a process of repeated particle attachment and facet stabilization. Ex situ and liquid-phase TEM observations show that a balance between particle attachment biased to occur near the star points, preferential growth along the [100] direction, and stabilization of (111) facets is critical to forming star-shaped particles. Molecular simulations predict that interaction strengths between peptoids and distinct Au facets differ signific2022-01-01T00:00:00Z2022 Mar2025-04-05T10:45:30.894Z2025-04-05T10:45:30.894ZS-EPMC92584403516770910.1002/anie.202201980