biostudies-literatureUnknown63(7)Burggraaff CNWe aimed to determine the added value of baseline metabolic tumor volume (MTV) and interim PET (I-PET) to the age-adjusted international prognostic index (aaIPI) to predict 2-y progression-free survival (PFS) in diffuse large B-cell lymphoma. Secondary objectives were to investigate optimal I-PET response criteria (using Deauville score [DS] or quantitative change in SUV_max [ΔSUV_max] between baseline and I-PET4 [observational I-PET scans after 4 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone administered in 2-wk intervals with intensified rituximab in the first 4 cycles [R(R)-CHOP14]). <b>Methods:</b> I-PET4 scans in the HOVON-84 (Hemato-Oncologie voor Volwassenen Nederland [Haemato Oncology Foundation for Adults in the Netherlands]) rJournal of nuclear medicine : official publication, Society of Nuclear Medicine1001-1007https://www.ebi.ac.uk/biostudies/studies/S-EPMC9258573biostudies-literature¹⁸F-FDG PET Improves Baseline Clinical Predictors of Response in Diffuse Large B-Cell Lymphoma: The HOVON-84 Study.PMC9258573Burggraaff CNde Keizer Bvan der Holt BEertink JJZijlstra JMArens AIJHOVON Imaging Working Group and the HOVON Lymphoma Working GroupPieplenbosch SLugtenburg PJHeymans MWWiegers SEde Vet HCWBoellaard RHoekstra OSfalse¹⁸F-FDG PET Improves Baseline Clinical Predictors of Response in Diffuse Large B-Cell Lymphoma: The HOVON-84 Study.We aimed to determine the added value of baseline metabolic tumor volume (MTV) and interim PET (I-PET) to the age-adjusted international prognostic index (aaIPI) to predict 2-y progression-free survival (PFS) in diffuse large B-cell lymphoma. Secondary objectives were to investigate optimal I-PET response criteria (using Deauville score [DS] or quantitative change in SUV_max [ΔSUV_max] between baseline and I-PET4 [observational I-PET scans after 4 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone administered in 2-wk intervals with intensified rituximab in the first 4 cycles [R(R)-CHOP14]). <b>Methods:</b> I-PET4 scans in the HOVON-84 (Hemato-Oncologie voor Volwassenen Nederland [Haemato Oncology Foundation for Adults in the Netherlands]) r2022-01-01T00:00:00Z2022 Jul2025-04-22T10:10:06.169Z2025-04-05T23:30:13.519ZS-EPMC92585733467511210.2967/jnumed.121.262205