biostudies-literatureUnknown63(7)Alberge JBThe International Myeloma Working Group recently fully incorporated ¹⁸F-FDG PET into multiple myeloma (MM) diagnosis and response evaluation. Moreover, a few studies demonstrated the prognostic value of several biomarkers extracted from this imaging at baseline. Before these ¹⁸F-FDG PET biomarkers could be fully endorsed as risk classifiers by the hematologist community, further characterization of underlying molecular aspects was necessary. <b>Methods:</b> Reported prognostic biomarkers (¹⁸F-FDG avidity, SUV_max, number of focal lesions, presence of paramedullary disease [PMD] or extramedullary disease) were extracted from ¹⁸F-FDG PET imaging at baseline in a group of 139 patients from CASSIOPET, a companion study of the CASSIOPEIA cohJournal of nuclear medicine : official publication, Society of Nuclear Medicine1008-1013https://www.ebi.ac.uk/biostudies/studies/S-EPMC9258580biostudies-literatureMolecular Signature of ¹⁸F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study.PMC9258580Touzeau CCherel MWuilleme SCorre JJamet BCaillon HBailly CMoreau PBene MCKampfenkel TBodet-Milin CCarlier TAlberge JBSonneveld PAvet-Loiseau Hvan Duin MKraeber-Bodere FMagrangeas FMinvielle SfalseMolecular Signature of ¹⁸F-FDG PET Biomarkers in Newly Diagnosed Multiple Myeloma Patients: A Genome-Wide Transcriptome Analysis from the CASSIOPET Study.The International Myeloma Working Group recently fully incorporated ¹⁸F-FDG PET into multiple myeloma (MM) diagnosis and response evaluation. Moreover, a few studies demonstrated the prognostic value of several biomarkers extracted from this imaging at baseline. Before these ¹⁸F-FDG PET biomarkers could be fully endorsed as risk classifiers by the hematologist community, further characterization of underlying molecular aspects was necessary. <b>Methods:</b> Reported prognostic biomarkers (¹⁸F-FDG avidity, SUV_max, number of focal lesions, presence of paramedullary disease [PMD] or extramedullary disease) were extracted from ¹⁸F-FDG PET imaging at baseline in a group of 139 patients from CASSIOPET, a companion study of the CASSIOPEIA coh2022-01-01T00:00:00Z2022 Jul2025-04-22T10:12:25.514Z2025-04-05T23:28:19.327ZS-EPMC92585803508689710.2967/jnumed.121.262884