biostudies-literatureLessard SNIEHS NIH HHSNHLBI NIH HHS903838https://www.ebi.ac.uk/biostudies/studies/S-EPMC9260508biostudies-literatureUnknown9<h4>Introduction</h4>Up to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The underlying mechanism of inhibitor development remains poorly understood. The My Life, Our Future Research Repository (MLOF RR) has gathered <i>F8</i> and <i>F9</i> mutational information, phenotypic data, and biological material from over 11,000 participants with hemophilia A (HA) and B as well as carriers enrolled across US hemophilia treatment centers, including over 5,000 whole-genome sequences. Identifying genes associated with inhibitors may contribute to our understanding of why certain patients develop those neutralizing antibodies.<h4>Aim and methods</h4>Here, we performed a genome-wide association study and gene-based analyFrontiers in medicineGenome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository.PMC9260508U01 HL120393HHSN268201800001CHHSN268201500016CR01 HL120393R01 HL117626HHSN268201600033CLessard SKlinger KHe CHarris TLoh CDumont JRajpal DKfalseGenome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository.<h4>Introduction</h4>Up to 30% of individuals with hemophilia A develop inhibitors to replacement factor VIII (FVIII), rendering the treatment ineffective. The underlying mechanism of inhibitor development remains poorly understood. The My Life, Our Future Research Repository (MLOF RR) has gathered <i>F8</i> and <i>F9</i> mutational information, phenotypic data, and biological material from over 11,000 participants with hemophilia A (HA) and B as well as carriers enrolled across US hemophilia treatment centers, including over 5,000 whole-genome sequences. Identifying genes associated with inhibitors may contribute to our understanding of why certain patients develop those neutralizing antibodies.<h4>Aim and methods</h4>Here, we performed a genome-wide association study and gene-based analy2022-01-01T00:00:00Z20222026-05-28T04:57:44.56Z2022-07-20T07:51:26.921ZS-EPMC92605083581478010.3389/fmed.2022.903838