biostudies-literatureRatnayake RInstitute of Population and Public Healthe061206https://www.ebi.ac.uk/biostudies/studies/S-EPMC9260795biostudies-literatureUnknown12(7)<h4>Introduction</h4>Cholera outbreaks in fragile settings are prone to rapid expansion. Case-area targeted interventions (CATIs) have been proposed as a rapid and efficient response strategy to halt or substantially reduce the size of small outbreaks. CATI aims to deliver synergistic interventions (eg, water, sanitation, and hygiene interventions, vaccination, and antibiotic chemoprophylaxis) to households in a 100-250 m 'ring' around primary outbreak cases.<h4>Methods and analysis</h4>We report on a protocol for a prospective observational study of the effectiveness of CATI. Médecins Sans Frontières (MSF) plans to implement CATI in the Democratic Republic of the Congo (DRC), Cameroon, Niger and Zimbabwe. This study will run in parallel to each implementation. The primary outcome is the cBMJ openEffectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study.PMC9260795DFS-164266Ciglenecki IOuamba JPEpicentre and MSF CATI Working GroupAssao BToure ONdombe RChecchi FBoum YPeyraud NRatnayake RNtone RMalik DLightowler MSagara JAGakima PLuquero FBachy CAlia MIssa-Soumana AMMutubuki HMukamba Musenga EMimbu ND'hondt RTraore MGignoux EFai KNAscorra AWelo POD'Mello-Guyett LHenry-Ostian CEdmunds WJPorten KMiwanda BPanunzi IAzman ASFinger FSoumana IfalseEffectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study.<h4>Introduction</h4>Cholera outbreaks in fragile settings are prone to rapid expansion. Case-area targeted interventions (CATIs) have been proposed as a rapid and efficient response strategy to halt or substantially reduce the size of small outbreaks. CATI aims to deliver synergistic interventions (eg, water, sanitation, and hygiene interventions, vaccination, and antibiotic chemoprophylaxis) to households in a 100-250 m 'ring' around primary outbreak cases.<h4>Methods and analysis</h4>We report on a protocol for a prospective observational study of the effectiveness of CATI. Médecins Sans Frontières (MSF) plans to implement CATI in the Democratic Republic of the Congo (DRC), Cameroon, Niger and Zimbabwe. This study will run in parallel to each implementation. The primary outcome is the c2022-01-01T00:00:00Z2022 Jul2025-04-26T13:07:11.436Z2025-04-26T13:07:11.436ZS-EPMC92607953579392410.1136/bmjopen-2022-061206