{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Almodovar-Paya C"],"funding":["Miguel Servet contract to M.F.-V.","European Regional Development Fund (ERDF)/European Social Fund “Investing in your future”","Agència de Gestió d'Ajuts Universitaris i de Recerca","Instituto de Salud Carlos III","Acadèmia de les Ciències Mèdiques i de la Salut de Catalunya i de Balears","Acadèmia de les Ciències Mèdiques i de la Salut de Catalunya i de Balears (predoctoral contract to C.A.-P.)","Instituto de Salud Carlos III through a PFIS predoctoral contract to M.G.-R.","Fundación Alicia Koplowitz","Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR)"],"pagination":["7456"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9267632"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(13)"],"pubmed_abstract":["Included in the neurotrophins family, the Neuritin 1 gene (<i>NRN1</i>) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of <i>NRN1</i> with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case-control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of <i>NRN1</i> on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age"],"journal":["International journal of molecular sciences"],"pubmed_title":["<i>NRN1</i> Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches."],"pmcid":["PMC9267632"],"funding_grant_id":["2017SGR1271","CP20/00072","2017SGR1271 and 2017SGR1577","FI19/0352","2017SGR1577"],"pubmed_authors":["Cuesta MJ","Salvador R","Parellada M","Fananas L","Callado LF","Gallego C","Giralt-Lopez M","Maristany T","Munoz MJ","Pomarol-Clotet E","Sarro S","Lazaro L","Almodovar-Paya C","Miret S","Guerrero-Pedraza A","Fatjo-Vilas M","Guardiola-Ripoll M","Salgado-Pineda P","Carrion MI","Arias B"],"additional_accession":[]},"is_claimable":false,"name":"<i>NRN1</i> Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches.","description":"Included in the neurotrophins family, the Neuritin 1 gene (<i>NRN1</i>) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of <i>NRN1</i> with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case-control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of <i>NRN1</i> on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-08T03:12:01.893Z","creation":"2022-07-21T09:36:18.041Z"},"accession":"S-EPMC9267632","cross_references":{"pubmed":["35806464"],"doi":["10.3390/ijms23137456"]}}