biostudies-literatureWelch BMNIEHS NIH HHSNIH HHS895-905https://www.ebi.ac.uk/biostudies/studies/S-EPMC9274448biostudies-literatureUnknown176(9)<h4>Importance</h4>Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth.<h4>Objective</h4>To investigate the prospective association between urinary biomarkers of phthalates in pregnancy and preterm birth among individuals living in the US.<h4>Design, setting, and participants</h4>Individual-level data were pooled from 16 preconception and pregnancy studies conducted in the US. Pregnant individuals who delivered between 1983 and 2018 and provided 1 or more urine samples during pregnancy were included.<h4>Exposures</h4>Urinary phthalate metabolites were quantified as biomarkers of phthalate exposure. Concentrations of 11 phthalate metabolites were standardized for urine dilution and mean repeated measurements across pregnancy were calculated.<h4>MJAMA pediatricsAssociations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts.PMC9274448P01 ES009605L40 ES032257U24 ES028529T32 ES007018P30 ES010126U24 ES028533UH3 OD023251P30 ES017885R01 ES031591P42 ES017198R01 ES030078P30 ES006096P30 ES023513R24 ES028533O'Brien KMWang CNewman RBAlshawabkeh ANRauh VADrobnis EZPooled Phthalate Exposure and Preterm Birth Study GroupWatkins DJJames-Todd TDabelea DMesserlian CChristenbury KEJukic AMZWeinberg CRCordero JFBinder AMSwan SHSchmidt RJWelch BMFactor-Litvak PHauser REskenazi BWenzel AGBradman ABarrett ESBuckley JPCalafat AMHarley KGSparks AERich DQHertz-Picciotto INguyen RHNAalborg JPadmanabhan VStarling APKeil APFerguson KKWeinberger BEngel SMLanphear BPBush NRBraun JMZota ARBloom MSHolland NMichels KBBaird DDSathyanarayana SMcElrath TFMeeker JDZhang YYolton KWilcox AJCantonwine DEHerbstman JBRosen EMRedmon JBfalseAssociations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts.<h4>Importance</h4>Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth.<h4>Objective</h4>To investigate the prospective association between urinary biomarkers of phthalates in pregnancy and preterm birth among individuals living in the US.<h4>Design, setting, and participants</h4>Individual-level data were pooled from 16 preconception and pregnancy studies conducted in the US. Pregnant individuals who delivered between 1983 and 2018 and provided 1 or more urine samples during pregnancy were included.<h4>Exposures</h4>Urinary phthalate metabolites were quantified as biomarkers of phthalate exposure. Concentrations of 11 phthalate metabolites were standardized for urine dilution and mean repeated measurements across pregnancy were calculated.<h4>M2022-01-01T00:00:00Z2022 Sep2026-05-07T17:54:05.963Z2025-04-05T20:30:47.018ZS-EPMC92744483581633310.1001/jamapediatrics.2022.2252