{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sakamuri SS"],"funding":["NIA NIH HHS","NINDS NIH HHS"],"pagination":["1410-1424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9274865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(8)"],"pubmed_abstract":["Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The goal of our study is to characterize the impact of aging on brain microvascular energetics. We measured the oxygen consumption and extracellular acidification rates of freshly isolated brain microvessels (BMVs) from young (2-4 months) and aged (20-22 months) C57Bl/6 male mice. Cellular ATP production in BMVs was predominantly dependent on oxidative phosphorylation (OXPHOS) with glucose as the preferred energy substrate. Aged BMVs exhibit lower ATP production rate with diminished OXPHOS and glycolytic rate accompanied by increased utilization of glutamine. Impairments of glycolysis displayed by aged BMVs incl"],"journal":["Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism"],"pubmed_title":["Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways."],"pmcid":["PMC9274865"],"funding_grant_id":["R01 NS096237","R01 NS114286","R01 AG047296","R01 AG074489","R01 NS094834","R01 AG049821"],"pubmed_authors":["Kolli L","Atochin DN","Sure VN","Katakam PV","Sakamuri SS","Murfee WL","Mostany R","Wang X","Bix GJ","Evans WR","Sperling JA"],"additional_accession":[]},"is_claimable":false,"name":"Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways.","description":"Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The goal of our study is to characterize the impact of aging on brain microvascular energetics. We measured the oxygen consumption and extracellular acidification rates of freshly isolated brain microvessels (BMVs) from young (2-4 months) and aged (20-22 months) C57Bl/6 male mice. Cellular ATP production in BMVs was predominantly dependent on oxidative phosphorylation (OXPHOS) with glucose as the preferred energy substrate. Aged BMVs exhibit lower ATP production rate with diminished OXPHOS and glycolytic rate accompanied by increased utilization of glutamine. Impairments of glycolysis displayed by aged BMVs incl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-04T04:58:24.449Z","creation":"2025-04-19T13:32:55.606Z"},"accession":"S-EPMC9274865","cross_references":{"pubmed":["35296173"],"doi":["10.1177/0271678x211069266","10.1177/0271678X211069266"]}}