biostudies-literatureUnknown27(1)Hamdy MMAssiut University<h4>Background</h4>Chronic renal failure (CRF) is a progressive loss of renal function that lead to reduced sodium filtration and inappropriate suppression of tubular reabsorption that ultimately leads to volume expansion. The aim of this study was to study the efficacy of furosemide and tadalafil nanoforms compared to conventional forms against adenine-induced CRF rat-model.<h4>Methods</h4>Addition of 0.75% adenine to the diet of rats for 4 weeks gained general acceptance as a model to study kidney damage as this intervention mimicked most of the structural and functional changes seen in human chronic kidney disease Urine analysis, histopathological changes and immunohistochemical expression of caspase-3 and interleukin-1 beta (IL-1β) in renal tissues were performed.<h4>Results</h4>Our reEuropean journal of medical research117https://www.ebi.ac.uk/biostudies/studies/S-EPMC9275182biostudies-literatureEffects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats.PMC9275182Abdel-Rahman MSSabra MSHamdy MMBadary DMfalseEffects of furosemide and tadalafil in both conventional and nanoforms against adenine-induced chronic renal failure in rats.<h4>Background</h4>Chronic renal failure (CRF) is a progressive loss of renal function that lead to reduced sodium filtration and inappropriate suppression of tubular reabsorption that ultimately leads to volume expansion. The aim of this study was to study the efficacy of furosemide and tadalafil nanoforms compared to conventional forms against adenine-induced CRF rat-model.<h4>Methods</h4>Addition of 0.75% adenine to the diet of rats for 4 weeks gained general acceptance as a model to study kidney damage as this intervention mimicked most of the structural and functional changes seen in human chronic kidney disease Urine analysis, histopathological changes and immunohistochemical expression of caspase-3 and interleukin-1 beta (IL-1β) in renal tissues were performed.<h4>Results</h4>Our re2022-01-01T00:00:00Z2022 Jul2025-04-18T23:00:14.509Z2025-04-07T10:44:14.722ZS-EPMC92751823582096310.1186/s40001-022-00747-3