biostudies-literatureUnknownRetel Helmrich IRANational Institute for Health Research (NIHR)Seventh Framework ProgrammeAcademy of Medical Sciences<h4>Background</h4>Following traumatic brain injury (TBI), the clinical focus is often on disability. However, patients' perceptions of well-being can be discordant with their disability level, referred to as the 'disability paradox'. We aimed to examine the relationship between disability and health-related quality of life (HRQoL) following TBI, while taking variation in personal, injury-related and environment factors into account.<h4>Methods</h4>We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. Disability was assessed 6 months post-injury by the Glasgow Outcome Scale-Extended (GOSE). HRQoL was assessed by the SF-12v2 physical and mental component summary scores and the Quality of Life after Traumatic Brain Injury overall scaJournal of neurology, neurosurgery, and psychiatryjnnp-2021-326615https://www.ebi.ac.uk/biostudies/studies/S-EPMC9279746biostudies-literatureDiscrepancy between disability and reported well-being after traumatic brain injury.PMC9279746FP7/2007-2013602150ACF-2009-14-007AMS-CSF4-NewcombeRadoi AWilliams GRossi SAkerlund CGolubovic JZiverte ARossaint RStanworth SPosti JPGalanaud DCastano-Leon AMValeinis EPerera NWijk RPJVSchafer NStamatakis ESteen GVLightfoot RKornaropoulos EVamos ZSmielewski PJiang JYFoks KPolinder SCiterio GRhodes JSkandsen TZeiler FAGrossi FGeorge PRipatti SYlen PEsser PBrinck VLevi LManara AGlocker BGravesteijn BHaitsma ILegrand VTamas VMcMahon CPraag DVDixit ATamosuitis TCarbonara MParizel PMRocka SMattern JSakowitz OCoburn MAndreassen LAmrein KWinzeck SDijck JVWang KKManley GVespa PMRoise ORosenlund CDepreitere BBlaabjerg MMajdan MGupta DAudibert GMenovsky TNewcombe VTaylor MSChevallard GBenali HMurray Lvan Klaveren DAo BTHelseth ENelson DVyvere TVTudora CMLecky FCzeiter EVoormolen DVulekovic PFurmanov ACurry NDonoghue ETakala RJones KDawes HĐilvesi ĐCzosnyka MMikolic ABeauvais RYounsi ARichter SBellander BMLanyon LStevens RDreier JPomposo IBragge PRosenfeld JVOlubukola OGantner DSanchez-Porras RTolias CBeer RJohnson FCENTER-TBI participants and investigatorsZoerle TWolf SMarechal HVajkoczy PPeul WAndelic NMelegh BHelbok RPersona PMaegele MVik ARambadagalla MCalappi EChieregato APuybasset LTibboel DDahyot-Fizelier CGomez PKowark ACooper JDRusnak MBrooker JWilson LMartino CPalotie AOrtolano FKondziella DHecke WVGratz JSewalt CVolovici VZelinkova VDuliere GLVerheyden JRagauskas AMenon DRichardson SGagliardo PLaureys SVargiolu ABoogert HDHorton LNaalt JVJagt MVVan Veen ESorinola AJacobs BEzer ETrapani TBeretta LEssen TAVTheadom ALedoux DVega EThomas MAzouvi PNieboer DSandor JSteyerberg EWPirinen MStocchetti NCavallo SPayen JFDegos VKoskinen LOCalvi MRSchou RFHeugten CVCabeleira MAzzolini MLSundstrom NSchwendenwein EStewart WMaas AVallance SBerardino MBrazinova AColes JNegru AKeyser VFrisvold SRoe CUnterberg ACovic ALejeune AVelt KCorreia MGao GBullinger MCaccioppola AHutchinson PJWiegers ESchoechl HGhuysen ASchmidt SGiga LPerlbarg VSchoonman GPiippo-Karjalainen AHaagsma JARetel Helmrich IRABelli ATimmers MLozano GCKompanje ELefering RErcole AJankowski SHuijben JBartels RBuki ALagares AYang ZTenovuo ONyiradi JVilcinis RKaran MLingsma HFabricius MRueckert DMisset BFeigin VLRosenthal GDark PPles HOresic MClusmann HRaj RKovacs NBrorsson CAnke ASahuquillo JGruen RLRosand JMaas AIJarrett MSteinbuchel NVBarzo PKolias AGCorte FDMuraleedharan VCameron PAntoni AfalseDiscrepancy between disability and reported well-being after traumatic brain injury.<h4>Background</h4>Following traumatic brain injury (TBI), the clinical focus is often on disability. However, patients' perceptions of well-being can be discordant with their disability level, referred to as the 'disability paradox'. We aimed to examine the relationship between disability and health-related quality of life (HRQoL) following TBI, while taking variation in personal, injury-related and environment factors into account.<h4>Methods</h4>We used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. Disability was assessed 6 months post-injury by the Glasgow Outcome Scale-Extended (GOSE). HRQoL was assessed by the SF-12v2 physical and mental component summary scores and the Quality of Life after Traumatic Brain Injury overall sca2022-01-01T00:00:00Z2022 May2026-06-20T04:47:58.03Z2026-06-20T03:10:26.834ZS-EPMC92797463553782310.1136/jnnp-2021-326615