{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng Z"],"funding":["Scientific Research Foundation of Hunan Provincial Education Department","National Natural Science Foundation of China","Natural Science Foundation of Hunan Province"],"pagination":["186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9281140"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Depression is a recurrent and devastating mental disease that is highly prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is detrimental to mental health. In recent years, an inflammatory hypothesis has been implicated in the pathogenesis of stress-induced depression. However, less attention has been given to the initial phases, when a series of stress reactions and immune responses are initiated. Peripheral CD4<sup>+</sup> T cells have been reported as the major contributors to the occurrence of mental disorders. Chronic stress exposure-evoked release of cytokines can promote the differentiation of peripheral CD4<sup>+</sup> cells into various phenotypes. Among them, Th17 cells have attracted much attention due to their high pathogen"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain."],"pmcid":["PMC9281140"],"funding_grant_id":["19B422","82171493","2021JJ30504"],"pubmed_authors":["Yuan T","Zhao B","Peng S","Tuo Q","Liao D","Lin K","Shi Z","Peng Z","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain.","description":"<h4>Background</h4>Depression is a recurrent and devastating mental disease that is highly prevalent worldwide. Prolonged exposure to stressful events or a stressful environment is detrimental to mental health. In recent years, an inflammatory hypothesis has been implicated in the pathogenesis of stress-induced depression. However, less attention has been given to the initial phases, when a series of stress reactions and immune responses are initiated. Peripheral CD4<sup>+</sup> T cells have been reported as the major contributors to the occurrence of mental disorders. Chronic stress exposure-evoked release of cytokines can promote the differentiation of peripheral CD4<sup>+</sup> cells into various phenotypes. Among them, Th17 cells have attracted much attention due to their high pathogen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T06:07:49.755Z","creation":"2022-07-19T08:13:11.404Z"},"accession":"S-EPMC9281140","cross_references":{"pubmed":["35836182"],"doi":["10.1186/s12974-022-02543-6"]}}