biostudies-literatureDudley DMNational Institute of Allergy and Infectious DiseasesNIH Office of the DirectorNIAID NIH HHSNational Institutes of HealthNIH HHSNIGMS NIH HHSe0266664https://www.ebi.ac.uk/biostudies/studies/S-EPMC9282477biostudies-literatureUnknown17(7)There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZPloS oneHuman immune globulin treatment controls Zika viremia in pregnant rhesus macaques.PMC9282477T32 GM135119R01Al116382P51OD011106RR15459-01R01 AI116382RR020141-01P51 OD011106Friedrich TCQiu HDudley DMTunga PGuo WMejia ASimmons HANewman CMEickhoff JCRazo EPermar SRMitzey ASemler MRWeiler AMO'Connor DHSingh TStewart LMYamamoto KDennis MFritsch MKGolos TGKoenig MRRybarczyk SZeng XAntony KMMohr ELAliota MTKohn SBreitbach MEShepherd PMKodihalli SSchotzko MAnderson DMfalseHuman immune globulin treatment controls Zika viremia in pregnant rhesus macaques.There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for Z2022-01-01T00:00:00Z20222025-04-18T22:58:43.643Z2025-04-07T10:41:10.531ZS-EPMC92824773583454010.1371/journal.pone.0266664