{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matzaraki V"],"funding":["European Research Council"],"pagination":["102391"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9283926"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55"],"pubmed_abstract":["Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated fungal-stimulated ROS production by immune cells isolated from a population-based cohort of approximately 200 healthy individuals (200FG cohort), and mapped ROS-quantitative trait loci (QTLs). We identified several genetic loci that regulate ROS levels (P < 9.99 × 10<sup>-6</sup>), with some of these loci being pathogen-specific, and others shared between the two fungi. These ROS-QTLs"],"journal":["Redox biology"],"pubmed_title":["Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis."],"pmcid":["PMC9283926"],"funding_grant_id":["833247"],"pubmed_authors":["Carvalho A","Kumar V","Keur N","Gresnigt MS","Beno A","van de Veerdonk FL","Joosten L","Campos A","Boahen C","Jaeger M","Matzaraki V","Goncalves SM","Leite L","Netea MG","Cunha C","Lacerda JF"],"additional_accession":[]},"is_claimable":false,"name":"Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis.","description":"Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated fungal-stimulated ROS production by immune cells isolated from a population-based cohort of approximately 200 healthy individuals (200FG cohort), and mapped ROS-quantitative trait loci (QTLs). We identified several genetic loci that regulate ROS levels (P < 9.99 × 10<sup>-6</sup>), with some of these loci being pathogen-specific, and others shared between the two fungi. These ROS-QTLs","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-09T14:27:27.825Z","creation":"2024-12-03T23:29:50.576Z"},"accession":"S-EPMC9283926","cross_references":{"pubmed":["35834984"],"doi":["10.1016/j.redox.2022.102391"]}}