biostudies-literatureMatzaraki VEuropean Research Council102391https://www.ebi.ac.uk/biostudies/studies/S-EPMC9283926biostudies-literatureUnknown55Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated fungal-stimulated ROS production by immune cells isolated from a population-based cohort of approximately 200 healthy individuals (200FG cohort), and mapped ROS-quantitative trait loci (QTLs). We identified several genetic loci that regulate ROS levels (P < 9.99 × 10^-6), with some of these loci being pathogen-specific, and others shared between the two fungi. These ROS-QTLsRedox biologyGenetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis.PMC9283926833247Carvalho AKumar VKeur NGresnigt MSBeno Avan de Veerdonk FLJoosten LCampos ABoahen CJaeger MMatzaraki VGoncalves SMLeite LNetea MGCunha CLacerda JFfalseGenetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis.Reactive oxygen species (ROS) are an essential component of the host defense against fungal infections. However, little is known about how common genetic variation affects ROS-mediated antifungal host defense. In the present study, we investigated the genetic factors that regulate ROS production capacity in response to the two human fungal pathogens: Candida albicans and Aspergillus fumigatus. We investigated fungal-stimulated ROS production by immune cells isolated from a population-based cohort of approximately 200 healthy individuals (200FG cohort), and mapped ROS-quantitative trait loci (QTLs). We identified several genetic loci that regulate ROS levels (P < 9.99 × 10^-6), with some of these loci being pathogen-specific, and others shared between the two fungi. These ROS-QTLs2022-01-01T00:00:00Z2022 Sep2026-05-09T14:27:27.825Z2024-12-03T23:29:50.576ZS-EPMC92839263583498410.1016/j.redox.2022.102391