{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goel RR"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIAMS NIH HHS"],"pagination":["abm0829"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9284784"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["374(6572)"],"pubmed_abstract":["The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2–naïve and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, and early CD4<sup>+</sup> T cell responses correlated with long-term humoral immunity. Recall responses to vaccination in indivi"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern."],"pmcid":["PMC9284784"],"funding_grant_id":["R38 HL143613","R01 AI155577","R01 AI105343","R01 AI152236","T32 AI070077","P01 AI108545","T32 AI055400","U19 AI082630","T32 AR076951","R21 AI142638","U19 AI149680","T32 CA009140","P30 AI045008"],"pubmed_authors":["Drapeau EM","Sette A","Herring S","Vella LA","Hamilton JT","Korte S","Kuthuru O","Meng W","Awofolaju M","Long S","Davenport MP","Hensley SE","Goel RR","Greenplate AR","Painter MM","Wherry EJ","Gouma S","Frank I","Luning Prak ET","UPenn COVID Processing Unit‡","Bates P","Giles JR","Dysinger S","Baxter AE","Oldridge DA","D'Andrea K","Hicks P","Sharma H","Apostolidis SA","Mathew D","Adamski S","Pattekar A","Grifoni A","Reynaldi A","McLaughlin M","Rosenfeld AM","Dougherty J","Weiskopf D","Kuri-Cervantes L","Lundgreen KA","Weirick ME","Williams JC","Hicks A","Betts MR","Khoury DS","McAllister CM","Tanenbaum N"],"additional_accession":[]},"is_claimable":false,"name":"mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.","description":"The durability of immune memory after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination remains unclear. In this study, we longitudinally profiled vaccine responses in SARS-CoV-2–naïve and –recovered individuals for 6 months after vaccination. Antibodies declined from peak levels but remained detectable in most subjects at 6 months. By contrast, mRNA vaccines generated functional memory B cells that increased from 3 to 6 months postvaccination, with the majority of these cells cross-binding the Alpha, Beta, and Delta variants. mRNA vaccination further induced antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, and early CD4<sup>+</sup> T cell responses correlated with long-term humoral immunity. Recall responses to vaccination in indivi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-09T14:27:13.992Z","creation":"2025-04-04T03:20:21.209Z"},"accession":"S-EPMC9284784","cross_references":{"pubmed":["34648302"],"doi":["10.1126/science.abm0829"]}}