biostudies-literatureUnknown13Zhang K<h4>Background</h4>Parathyroid carcinoma (PC) is a rare malignancy without a commonly acknowledged prognostic assessment and treatment system. This study captures how independent prognostic factors and tumor size correlate with outcomes in patients with PC.<h4>Methods</h4>The Surveillance, Epidemiology, and End Results database was used to perform a retrospective analysis on PC patients from 2000 to 2018. Univariate and multivariable survival analyses were performed to evaluate cancer-specific survival (CSS) and overall survival (OS), to identify independent prognostic factors in the PC patient population. A generalized additive model was applied to conduct smooth curve fitting and to examine the association between tumor size and relative risk of death.<h4>Results</h4>A total of 590 patieFrontiers in endocrinology882579https://www.ebi.ac.uk/biostudies/studies/S-EPMC9285012biostudies-literatureNon-Linear Correlation Between Tumor Size and Survival Outcomes for Parathyroid Carcinoma: A SEER Population-Based Cohort Study.PMC9285012Li ZZhang KSu AZhu JWei TZhao WWang XHe LChen YWfalseNon-Linear Correlation Between Tumor Size and Survival Outcomes for Parathyroid Carcinoma: A SEER Population-Based Cohort Study.<h4>Background</h4>Parathyroid carcinoma (PC) is a rare malignancy without a commonly acknowledged prognostic assessment and treatment system. This study captures how independent prognostic factors and tumor size correlate with outcomes in patients with PC.<h4>Methods</h4>The Surveillance, Epidemiology, and End Results database was used to perform a retrospective analysis on PC patients from 2000 to 2018. Univariate and multivariable survival analyses were performed to evaluate cancer-specific survival (CSS) and overall survival (OS), to identify independent prognostic factors in the PC patient population. A generalized additive model was applied to conduct smooth curve fitting and to examine the association between tumor size and relative risk of death.<h4>Results</h4>A total of 590 patie2022-01-01T00:00:00Z20222025-04-04T09:41:42.928Z2025-04-04T09:41:42.928ZS-EPMC92850123584629910.3389/fendo.2022.882579