{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xi X"],"funding":["National Natural Science Foundation of China"],"pagination":["854940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9285403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>Changes in the intestinal microenvironment affected bone destruction in rheumatoid arthritis (RA), and spleen deficiency (SD) was closely related to the intestinal microenvironment. In this study, we aimed to explore the aggravation of SD on collagen-induced arthritis (CIA) and the bone protection of compound Xiong Fu powder (XFP) on CIA with SD (SD-CIA) based on the intestinal microenvironment.<h4>Method</h4>An SD-CIA rat model was established using <i>Rheum officinale</i> Baill. decoction combined with CIA and then treated with XFP. The aggravating action of SD on CIA rats and the efficacy of XFP were evaluated using AI scores, H&E staining of the joint, and level of serum anti-collagen type II antibody (Col II Ab). Bone destruction was assessed by micro-CT and TRACP s"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["Xiong Fu Powder Regulates the Intestinal Microenvironment to Protect Bones Against Destruction in Collagen-Induced Arthritis Rat Models."],"pmcid":["PMC9285403"],"funding_grant_id":["81673844"],"pubmed_authors":["Xi X","Xia Y","Li X","Ye Q","Lu X","Xiao C","Fan D"],"additional_accession":[]},"is_claimable":false,"name":"Xiong Fu Powder Regulates the Intestinal Microenvironment to Protect Bones Against Destruction in Collagen-Induced Arthritis Rat Models.","description":"<h4>Background</h4>Changes in the intestinal microenvironment affected bone destruction in rheumatoid arthritis (RA), and spleen deficiency (SD) was closely related to the intestinal microenvironment. In this study, we aimed to explore the aggravation of SD on collagen-induced arthritis (CIA) and the bone protection of compound Xiong Fu powder (XFP) on CIA with SD (SD-CIA) based on the intestinal microenvironment.<h4>Method</h4>An SD-CIA rat model was established using <i>Rheum officinale</i> Baill. decoction combined with CIA and then treated with XFP. The aggravating action of SD on CIA rats and the efficacy of XFP were evaluated using AI scores, H&E staining of the joint, and level of serum anti-collagen type II antibody (Col II Ab). Bone destruction was assessed by micro-CT and TRACP s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-02T22:40:40.066Z","creation":"2025-04-04T22:04:10.648Z"},"accession":"S-EPMC9285403","cross_references":{"pubmed":["35846762"],"doi":["10.3389/fcimb.2022.854940"]}}