{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Dorth D"],"funding":["Dutch Research Council (NWO)"],"pagination":["e4653"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9285940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(5)"],"pubmed_abstract":["Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R<sub>2</sub> <sup>(*)</sup> relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R<sub>2</sub> <sup>(*)</sup> versus contrast concentration relation under varying physiological and technical conditions"],"journal":["NMR in biomedicine"],"pubmed_title":["Dependency of R<sub>2</sub> and R<sub>2</sub> * relaxation on Gd-DTPA concentration in arterial blood: Influence of hematocrit and magnetic field strength."],"pmcid":["PMC9285940"],"funding_grant_id":["17079"],"pubmed_authors":["Hernandez-Tamames JA","van Osch MJP","de Bresser J","Poot DHJ","Smits M","Venugopal K","Hirschler L","van Dorth D","Debacker CS"],"additional_accession":[]},"is_claimable":false,"name":"Dependency of R<sub>2</sub> and R<sub>2</sub> * relaxation on Gd-DTPA concentration in arterial blood: Influence of hematocrit and magnetic field strength.","description":"Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R<sub>2</sub> <sup>(*)</sup> relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R<sub>2</sub> <sup>(*)</sup> versus contrast concentration relation under varying physiological and technical conditions","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-19T09:24:36.603Z","creation":"2022-08-05T06:26:27.355Z"},"accession":"S-EPMC9285940","cross_references":{"pubmed":["34816501"],"doi":["10.1002/nbm.4653"]}}