biostudies-literaturevan Dorth DDutch Research Council (NWO)e4653https://www.ebi.ac.uk/biostudies/studies/S-EPMC9285940biostudies-literatureUnknown35(5)Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R₂ ^(*) relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R₂ ^(*) versus contrast concentration relation under varying physiological and technical conditionsNMR in biomedicineDependency of R₂ and R₂ * relaxation on Gd-DTPA concentration in arterial blood: Influence of hematocrit and magnetic field strength.PMC928594017079Hernandez-Tamames JAvan Osch MJPde Bresser JPoot DHJSmits MVenugopal KHirschler Lvan Dorth DDebacker CSfalseDependency of R₂ and R₂ * relaxation on Gd-DTPA concentration in arterial blood: Influence of hematocrit and magnetic field strength.Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R₂ ^(*) relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R₂ ^(*) versus contrast concentration relation under varying physiological and technical conditions2022-01-01T00:00:00Z2022 May2025-04-19T09:24:36.603Z2022-08-05T06:26:27.355ZS-EPMC92859403481650110.1002/nbm.4653