{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zanotto T"],"funding":["National Multiple Sclerosis Society","Mentor-based Rehabilitation Research Post-doctoral fellow grant"],"pagination":["e0271688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9286252"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(7)"],"pubmed_abstract":["Background
Frailty is a biological syndrome arising from cumulative declines across multiple physiologic systems. Although recent reports have described elevated frailty levels in people with multiple sclerosis (MS) with minimal to moderate disability, very little is known about frailty in individuals with severe disability. The objective of the current investigation was to evaluate frailty through the deficit accumulation model and to explore the relationship of frailty with MS clinical subtypes, disease duration and fall-history in wheelchair users living with MS.Materials and methods
Standard validated procedures were used to calculate a frailty index in 45 wheelchair and scooter users living with MS (median age = 60.0[16.0] years, 82.2% female, patient determined diseas"],"journal":["PloS one"],"pubmed_title":["Frailty among people with multiple sclerosis who are wheelchair users."],"pmcid":["PMC9286252"],"funding_grant_id":["RG-1701-26862","MB-1807-31633"],"pubmed_authors":["Rice LA","Zanotto T","Sosnoff JJ"],"additional_accession":[]},"is_claimable":false,"name":"Frailty among people with multiple sclerosis who are wheelchair users.","description":"Background
Frailty is a biological syndrome arising from cumulative declines across multiple physiologic systems. Although recent reports have described elevated frailty levels in people with multiple sclerosis (MS) with minimal to moderate disability, very little is known about frailty in individuals with severe disability. The objective of the current investigation was to evaluate frailty through the deficit accumulation model and to explore the relationship of frailty with MS clinical subtypes, disease duration and fall-history in wheelchair users living with MS.Materials and methods
Standard validated procedures were used to calculate a frailty index in 45 wheelchair and scooter users living with MS (median age = 60.0[16.0] years, 82.2% female, patient determined diseas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T01:50:34.206Z","creation":"2025-04-05T09:00:19.522Z"},"accession":"S-EPMC9286252","cross_references":{"pubmed":["35839220"],"doi":["10.1371/journal.pone.0271688"]}}