biostudies-literatureChowdhury RRHoward Hughes Medical InstituteNIA NIH HHSNIAID NIH HHSNHLBI NIH HHS1510-1530https://www.ebi.ac.uk/biostudies/studies/S-EPMC9286288biostudies-literatureUnknown130(10)<h4>Background</h4>Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.<h4>Methods</h4>We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.<h4>Results</h4>In addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cellsCirculation researchHuman Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.PMC9286288DP2 HL157540R01 HL134830F32 HL143847P01 AI153559R03 AG060182T32 AI007290Quertermous TTso AChien YHGulati GSAhmad HLee ASBakerman IJensen ASokol JKoyano TGopakumar JLiang GCheng PFong RBoyd JDavis MMD'Addabbo JLouis DMShankar VNguyen PKWoo YJChowdhury RRChan CKFWirka RWendel BSNau ANVeizades SJaiswal SHuang XSasagawa KfalseHuman Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.<h4>Background</h4>Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.<h4>Methods</h4>We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.<h4>Results</h4>In addition to macrophages, we found a high proportion of αβ T cells in the coronary plaques. Most of these T cells2022-01-01T00:00:00Z2022 May2026-05-28T06:15:19.402Z2024-11-12T18:05:33.869ZS-EPMC92862883543087610.1161/circresaha.121.32009010.1161/CIRCRESAHA.121.320090