{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taylor HA"],"funding":["British Heart Foundation","Biotechnology and Biological Sciences Research Council"],"pagination":["e13430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9286785"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(7)"],"pubmed_abstract":["β-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the β-secretase responsible for the production of β-amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and protein is also found in many cell types including pancreatic β-cells, adipocytes, hepatocytes, and vascular cells. Pathologically elevated BACE1 expression in these cells has been implicated in the development of metabolic diseases, including type 2 diabetes, obesity, and cardiovascular disease. In this review, we examine key questions surrounding the BACE1 literature, including how is BACE1 regulated and how dysregulation may occur in disease, and understand how BACE1 regulates metabolism via cleavage o"],"journal":["Obesity reviews : an official journal of the International Association for the Study of Obesity"],"pubmed_title":["BACE1: More than just a β-secretase."],"pmcid":["PMC9286785"],"funding_grant_id":["BB/V014358/1","FS/4yPhD/F/20/34130A","FS/4yPhD/F/20/34130","FS/4yPhD/F/20/34130C","FS/18/38/33659"],"pubmed_authors":["Taylor HA","Clavane EM","Meakin PJ","Przemylska L"],"additional_accession":[]},"is_claimable":false,"name":"BACE1: More than just a β-secretase.","description":"β-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the β-secretase responsible for the production of β-amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and protein is also found in many cell types including pancreatic β-cells, adipocytes, hepatocytes, and vascular cells. Pathologically elevated BACE1 expression in these cells has been implicated in the development of metabolic diseases, including type 2 diabetes, obesity, and cardiovascular disease. In this review, we examine key questions surrounding the BACE1 literature, including how is BACE1 regulated and how dysregulation may occur in disease, and understand how BACE1 regulates metabolism via cleavage o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-05T14:05:49.461Z","creation":"2025-02-19T01:10:35.113Z"},"accession":"S-EPMC9286785","cross_references":{"pubmed":["35119166"],"doi":["10.1111/obr.13430"]}}