biostudies-literatureUnknown8(1)Trugilho MROCoronavirus disease 2019 (COVID-19) has affected over 400 million people worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19, hypercoagulation and thrombosis have been described to directly contribute to lethality, pointing out platelets as an important SARS-CoV-2 target. In this work, we explored the platelet proteome of COVID-19 patients through a label-free shotgun proteomics approach to identify platelet responses to infection, as well as validation experiments in a larger patient cohort. Exclusively detected proteins (EPs) and differentially expressed proteins (DEPs) were identified in the proteomic dataset and thus classified into biological processes to map pathways correlated with pathogenesis. Significant changes in the expression of proteins relatCell death discovery324https://www.ebi.ac.uk/biostudies/studies/S-EPMC9287722biostudies-literaturePlatelet proteome reveals features of cell death, antiviral response and viral replication in covid-19.PMC9287722Bastos VABozza PTMandacaru SCPerales JGesto JSMCampos MMOliveira DMAzevedo-Quintanilha IGSantos MDMValente RHSouza TMLBozza FADias SSGMoraes ECSCarvalho PCHottz EDTrugilho MROfalsePlatelet proteome reveals features of cell death, antiviral response and viral replication in covid-19.Coronavirus disease 2019 (COVID-19) has affected over 400 million people worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19, hypercoagulation and thrombosis have been described to directly contribute to lethality, pointing out platelets as an important SARS-CoV-2 target. In this work, we explored the platelet proteome of COVID-19 patients through a label-free shotgun proteomics approach to identify platelet responses to infection, as well as validation experiments in a larger patient cohort. Exclusively detected proteins (EPs) and differentially expressed proteins (DEPs) were identified in the proteomic dataset and thus classified into biological processes to map pathways correlated with pathogenesis. Significant changes in the expression of proteins relat2022-01-01T00:00:00Z2022 Jul2026-05-09T22:03:51.878Z2024-11-08T18:01:15.86ZS-EPMC92877223584241510.1038/s41420-022-01122-1