biostudies-literatureMiro OMinisterio de Sanidad, Política Social e IgualdadInstituto de Salud Carlos IIIFundació la Marató de TV3Federación Española de Enfermedades RarasNovartis2225-2232https://www.ebi.ac.uk/biostudies/studies/S-EPMC9288737biostudies-literatureUnknown9(4)<h4>Aims</h4>The current study explores whether degree of inflammation, reflected by C-reactive protein (CRP) level, modifies the effect of intravenous (IV) corticosteroid administered in the emergency department (ED) on clinical outcomes in patients with acute heart failure (AHF).<h4>Methods and results</h4>We selected patients diagnosed with AHF in the ED, with confirmed N-terminal pro-B-type natriuretic peptide > 300 pg/mL and CRP > 5 mg/L in the ED from the Epidemiology of Acute Heart Failure in the Emergency Departments (EAHFE) registry. In these 1109 patients, 121 were treated by corticosteroid. The corticosteroid therapy hazard ratio (HR) for 30 day all-cause mortality was 1.26 [95% confidence interval (CI) 0.75-2.09, P = 0.38]. Although not statistically significant, HRs tended to ESC heart failureEffect of systemic corticosteroid therapy for acute heart failure patients with elevated C-reactive protein.PMC9288737PI18/00393PI15/007732015/2510PI18/00456PI15/01019Edwards CJacob JCotter GDavison BALlorens PMiro OTakagi KFreund YMebazaa AfalseEffect of systemic corticosteroid therapy for acute heart failure patients with elevated C-reactive protein.<h4>Aims</h4>The current study explores whether degree of inflammation, reflected by C-reactive protein (CRP) level, modifies the effect of intravenous (IV) corticosteroid administered in the emergency department (ED) on clinical outcomes in patients with acute heart failure (AHF).<h4>Methods and results</h4>We selected patients diagnosed with AHF in the ED, with confirmed N-terminal pro-B-type natriuretic peptide > 300 pg/mL and CRP > 5 mg/L in the ED from the Epidemiology of Acute Heart Failure in the Emergency Departments (EAHFE) registry. In these 1109 patients, 121 were treated by corticosteroid. The corticosteroid therapy hazard ratio (HR) for 30 day all-cause mortality was 1.26 [95% confidence interval (CI) 0.75-2.09, P = 0.38]. Although not statistically significant, HRs tended to 2022-01-01T00:00:00Z2022 Aug2025-04-21T23:00:23.126Z2025-04-05T18:57:06.972ZS-EPMC92887373539376210.1002/ehf2.13926